Gene: CFAP74
Official Full Name: cilia and flagella associated protein 74provided by HGNC
Gene Summary: Predicted to be involved in axoneme assembly. Located in cytoplasm; nucleus; and sperm flagellum. Implicated in primary ciliary dyskinesia. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24217 | CFAP74 Knockout cell line (HCT 116) | Human | CFAP74 | 1:2~1:4 | Negative | Online Inquiry |
KO24218 | CFAP74 Knockout cell line (HEK293) | Human | CFAP74 | 1:3~1:6 | Negative | Online Inquiry |
CFAP74 Gene Knockout Cell Lines are specialized cellular models designed for the precise study of the CFAP74 gene, which encodes a protein implicated in ciliated cell function and motility. By employing CRISPR-Cas9 technology, these cell lines have been engineered to lack functional CFAP74, allowing for the exploration of its biological roles, particularly in the context of cilia-related disorders. The knockout mechanism effectively disrupts the gene's ability to produce its target protein, thereby facilitating the identification of phenotypic alterations in cellular and molecular processes critical for understanding disease mechanisms.
The primary function of CFAP74 gene knockout cell lines is to serve as robust platforms for research into ciliary dynamics and related pathologies, such as primary ciliary dyskinesia. These models enable scientists to investigate cell motility, intracellular signaling pathways, and the impact of CFAP74 loss on cellular behavior. Moreover, they can be utilized in drug discovery processes to evaluate potential therapeutic interventions targeting related pathways.
The significance of CFAP74 gene knockout cell lines extends into both research and clinical applications, providing invaluable insights into the genetic basis of cilia-related diseases. Their utilization contributes to the growing body of knowledge necessary for developing effective diagnostics and treatment strategies. Furthermore, these cell lines offer a reproducible and reliable alternative to traditional models, significantly reducing variability in experimental outcomes.
What sets these knockout cell lines apart from other available models is their genetically precise modification, which ensures the specificity and reliability of results. Researchers can trust that the impacts observed in CFAP74 knockout models stem from the targeted gene disruption, rather than nonspecific off-target effects. This specificity makes them particularly advantageous for high-resolution studies of ciliary function and dysfunction.
For researchers and clinicians alike, CFAP74 Gene Knockout Cell Lines present a unique opportunity to advance understanding and innovation in ciliary research, making them a valuable asset in the toolkit of modern biological investigation. Backed by our company’s extensive expertise in genetic engineering and cell line development, we are committed to providing high-quality products that empower researchers to tackle complex biological questions effectively. Our dedication to scientific excellence ensures that you receive reliable, accessible, and thoroughly validated resources for your research needs.
Please note that all services are for research use only. Not intended for any clinical use.
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