Gene: CEP41
Official Full Name: centrosomal protein 41provided by HGNC
Gene Summary: This gene encodes a centrosomal and microtubule-binding protein which is predicted to have two coiled-coil domains and a rhodanese domain. In human retinal pigment epithelial cells the protein localized to centrioles and cilia. Mutations in this gene have been associated with Joubert Syndrome 15; an autosomal recessive ciliopathy and neurological disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21941 | CEP41 Knockout cell line (HeLa) | Human | CEP41 | 1:3~1:6 | Negative | Online Inquiry |
KO21942 | CEP41 Knockout cell line (HCT 116) | Human | CEP41 | 1:2~1:4 | Negative | Online Inquiry |
KO21943 | CEP41 Knockout cell line (HEK293) | Human | CEP41 | 1:3~1:6 | Negative | Online Inquiry |
KO21944 | CEP41 Knockout cell line (A549) | Human | CEP41 | 1:3~1:4 | Negative | Online Inquiry |
CEP41 Gene Knockout Cell Lines are specialized cell models engineered to have a targeted deletion of the CEP41 gene, which encodes a protein involved in ciliary function and cellular trafficking. These knockout cell lines serve as essential tools for investigating the role of CEP41 in cellular processes, such as motility, signaling pathways, and sensory functions. The mechanism of action for these cell lines involves the disruption of normal CEP41 protein function, which can lead to alterations in cilia morphology and signaling, thereby facilitating in-depth studies into related diseases and disorders.
The scientific importance of CEP41 Gene Knockout Cell Lines is underscored by their utility in both research and clinical applications. Researchers can leverage these models to explore the implications of CEP41 loss in ciliary dysfunction, which is associated with various conditions including ciliopathies and neurodegenerative diseases. Furthermore, they are integral for validating potential therapeutic targets and developing gene therapies, as they allow scientists to observe the effects of compensatory mechanisms in cells devoid of this critical gene.
Compared to other available knockout models, CEP41 Gene Knockout Cell Lines offer unique advantages, such as precise genome editing capabilities and the immediate availability of a well-characterized phenotype. This specificity enables researchers to obtain reliable data with fewer variables, resulting in higher reproducibility in experimental outcomes. Moreover, these cell lines can be easily adapted for high-throughput screening assays, thus accelerating the pace of discovery in biomedical research.
For researchers and clinicians in the fields of genetics, cell biology, and regenerative medicine, CEP41 Gene Knockout Cell Lines represent a valuable asset that enhances their investigative capabilities. Understanding the biological roles and implications of the CEP41 gene can yield insights into therapeutic interventions and improve patient outcomes.
As a company dedicated to advancing scientific discovery, we pride ourselves on providing high-quality, expertly characterized biological products that empower researchers in their quest for knowledge and innovation. Our commitment to excellence ensures that CEP41 Gene Knockout Cell Lines meet rigorous standards to facilitate groundbreaking research and clinical advancements.
Please note that all services are for research use only. Not intended for any clinical use.
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