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CEP170 Knockout Cell Lines

Gene: CEP170

Official Full Name: centrosomal protein 170provided by HGNC

Gene Summary: The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32626 CEP170 Knockout cell line (HeLa) Human CEP170 1:3~1:6 Negative Online Inquiry
KO32627 CEP170 Knockout cell line (HCT 116) Human CEP170 1:2~1:4 Negative Online Inquiry
KO32628 CEP170 Knockout cell line (HEK293) Human CEP170 1:3~1:6 Negative Online Inquiry
KO32629 CEP170 Knockout cell line (A549) Human CEP170 1:3~1:4 Negative Online Inquiry

Background

CEP170 Gene Knockout Cell Lines are genetically modified cell lines in which the CEP170 gene has been selectively disrupted. This knockout model serves as a valuable tool for studying the specific functions of CEP170 in cellular processes such as cell division, centrosome organization, and microtubule dynamics. The disruption of the CEP170 gene allows researchers to explore its role in cellular mechanisms, potentially leading to insights into diseases related to cell cycle regulation and cytoskeletal abnormalities.

The key function of these cell lines lies in their ability to facilitate functional studies of the CEP170 protein, which is implicated in maintaining centrosome integrity and supporting proper cell localization during mitosis. By using these knockout cell lines, researchers can observe differential cellular behavior compared to wild-type counterparts, which aids in elucidating the phenotypic consequences of CEP170 loss. This approach empowers scientists to investigate not just the biological functions of CEP170 but also its interactions with other proteins integral to the mitotic spindle assembly and chromosome segregation.

In the realm of scientific research and clinical application, CEP170 Gene Knockout Cell Lines are vital for dissecting the pathways involved in various cancers and other diseases associated with mitotic failure. Their application extends to drug discovery efforts, where identifying potential therapeutic targets necessitates a deep understanding of gene function in disease pathology.

These knockout cell lines offer significant advantages over traditional models, as they provide a clean genetic background devoid of confounding variables related to gene expression variability. Their use also reduces the need for labor-intensive gene silencing techniques, ensuring consistent and reproducible results. Furthermore, researchers can leverage these cell lines to explore the impact of pharmacological agents on cell cycle behaviors, leading to more informed therapeutic decisions.

For researchers and clinicians seeking to enhance their understanding of complex cellular dynamics, CEP170 Gene Knockout Cell Lines present an invaluable resource. They not only streamline experimental design but also foster innovation in identifying novel therapeutic approaches. With a robust foundation in genetic engineering and a commitment to advancing research tools, our company is dedicated to providing high-quality biological products that meet the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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