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CELSR3 Knockout Cell Lines

Gene: CELSR3

Official Full Name: cadherin EGF LAG seven-pass G-type receptor 3provided by HGNC

Gene Summary: This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38094 CELSR3 Knockout cell line (HeLa) Human CELSR3 1:3~1:6 Negative Online Inquiry
KO38095 CELSR3 Knockout cell line (HCT 116) Human CELSR3 1:2~1:4 Negative Online Inquiry
KO38096 CELSR3 Knockout cell line (HEK293) Human CELSR3 1:3~1:6 Negative Online Inquiry
KO38097 CELSR3 Knockout cell line (A549) Human CELSR3 1:3~1:4 Negative Online Inquiry

Background

CELSR3 Gene Knockout Cell Lines are genetically engineered cell systems designed for the focused study of the CELSR3 gene's role in cellular processes and disease mechanisms. CELSR3 (Cadherin EGF LAG Seven Pass G-type Receptor 3) is a member of the cadherin family and is implicated in critical functions such as neurodevelopment, cell signaling, and tissue organization. By utilizing CRISPR/Cas9 technology, these cell lines provide a powerful platform for investigating the gene’s function by enabling precise deletions or modifications of CELSR3, thus allowing researchers to study the resulting phenotypic changes.

The primary mechanism of action involves the targeted disruption of the CELSR3 gene, which facilitates the elucidation of its pathways and interactions within various physiological processes. This knockout model can mimic disease states associated with aberrant CELSR3 expression, making it invaluable for studying neurological disorders, developmental abnormalities, and cancer research.

The scientific importance of CELSR3 Gene Knockout Cell Lines extends to both fundamental research and translational applications. In research settings, these lines enable the exploration of cellular behaviors and signaling pathways critical to developmental biology and pathology. Clinically, understanding CELSR3's role could lead to the identification of novel therapeutic targets, enhancing treatment strategies for conditions where CELSR3 is implicated.

What sets our CELSR3 Gene Knockout Cell Lines apart from alternative products is their high specificity and efficiency, courtesy of our advanced genome-editing techniques and rigorous validation protocols. Unlike conventional cell lines, which may harbor off-target effects or residual gene expression, our knockout models ensure a clean slate for researchers to work with. This precision not only saves valuable time but also increases the reliability of experimental outcomes, making it a top choice for scientists striving for accuracy.

Investing in CELSR3 Gene Knockout Cell Lines means gaining access to a resource that empowers researchers and clinicians alike, providing unparalleled insight into complex biological questions. With a commitment to cutting-edge science and robust customer support, our company stands at the forefront of genetic research tools, equipping the scientific community with the products necessary to drive innovation and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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