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CELF2 Knockout Cell Lines

Gene: CELF2

Official Full Name: CUGBP Elav-like family member 2provided by HGNC

Gene Summary: Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31637 CELF2 Knockout cell line (HeLa) Human CELF2 1:3~1:6 Negative Online Inquiry
KO31638 CELF2 Knockout cell line (HEK293) Human CELF2 1:3~1:6 Negative Online Inquiry

Background

CELF2 Gene Knockout Cell Lines are engineered cellular models that possess a targeted deletion of the CELF2 gene, a critical regulator of alternative splicing and gene expression. These cell lines are produced using advanced CRISPR-Cas9 genome editing technology, which allows for precise disruption of the CELF2 gene, enabling researchers to investigate the functional role of CELF2 in cellular processes and disease mechanisms.

The primary function of CELF2 involves the modulation of mRNA splicing, influencing gene expression profiles that are pivotal in processes such as differentiation, development, and response to stress. By utilizing CELF2 Gene Knockout Cell Lines, scientists can study the downstream effects of CELF2 absence on RNA splicing events, cellular pathways, and phenotype alterations, providing valuable insights into various biological processes and potential therapeutic targets.

These cell lines hold substantial scientific importance in both research and clinical settings, particularly in the context of diseases associated with splicing dysregulation, such as cancer and neurodegenerative disorders. They enable researchers to elucidate the pathophysiology of these conditions and assess the impact of potential treatments, thereby advancing the field of molecular biology.

What sets our CELF2 Gene Knockout Cell Lines apart from existing alternatives is their high specificity and reliability. Unlike siRNA or overexpression approaches that may lead to off-target effects or variable expression levels, our knockout lines offer a stable, reproducible model for investigating gene function and phenotypic consequences without ambiguity. Additionally, these cell lines are thoroughly characterized and validated for consistent performance across experiments.

Researchers and clinicians seeking to explore the implications of CELF2 in their studies will find significant value in our product. It not only streamlines experimental design but also enhances the robustness of their findings, ultimately contributing to the development of innovative therapies.

Our company prides itself on its commitment to providing high-quality, scientifically validated biological products. With extensive expertise in cellular engineering and a robust portfolio, we aim to support the research community in unraveling complex biological questions.

Please note that all services are for research use only. Not intended for any clinical use.

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