Gene: CDC42
Official Full Name: cell division cycle 42provided by HGNC
Gene Summary: The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00261 | CDC42 gRNA1-gRNA2 KO plasmid | CDC42 | $850 | |||
KO00686 | CDC42 Knockout cell line(A549) | Human | CDC42 | 1:3~1:4 | Negative | Online Inquiry |
CDC42 Gene Knockout Cell Lines are engineered cellular models in which the CDC42 gene, a crucial regulator of cell polarity and cytoskeletal dynamics, has been selectively disrupted. This innovative product is designed to facilitate the study of CDC42's role in numerous biological processes, including cell migration, growth, and differentiation. By creating a knockout model, researchers can observe phenotypical changes and elucidate the downstream effects of CDC42 in signaling pathways, providing deeper insights into its function in both normal physiology and disease states.
The mechanism of action hinges on the strategic deletion of the CDC42 gene, leading to loss-of-function characteristics in a controlled cell environment. This allows scientists to investigate the specific cellular behaviors that depend on CDC42 activity. As such, these cell lines serve as valuable tools to explore the implications of CDC42 in cancer metastasis, neurological disorders, and immune responses, offering a platform for the development of new therapeutic strategies.
In research and clinical applications, CDC42 Gene Knockout Cell Lines hold significance for studies into the molecular underpinnings of diseases where CDC42 is implicated. Their utility extends to drug discovery, enabling the identification of potential therapeutic compounds that could reinstate normal cellular functions or inhibit pathological processes driven by CDC42 dysregulation.
One of the product's standout advantages is the precision and reliability associated with its creation. Unlike conventional models that may have variable expression levels of the target gene, these knockout cell lines provide a consistent background for experimental reproducibility. Furthermore, the specificity of the knockout minimizes off-target effects that can confound results, making it a superior choice for discerning the exact functions of CDC42 as compared to non-specific silencing techniques such as RNA interference.
For researchers and clinicians alike, the value of CDC42 Gene Knockout Cell Lines lies in their capacity to unravel complex cellular interactions and contribute systematically to the understanding of human diseases. Partnering with our company means accessing state-of-the-art biological products backed by extensive expertise and a commitment to providing the highest quality tools for scientific advancement.
Please note that all services are for research use only. Not intended for any clinical use.
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