Gene: CDC14B
Official Full Name: cell division cycle 14Bprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34052 | CDC14B Knockout cell line (HeLa) | Human | CDC14B | 1:3~1:6 | Negative | Online Inquiry |
KO34053 | CDC14B Knockout cell line (HCT 116) | Human | CDC14B | 1:2~1:4 | Negative | Online Inquiry |
KO34054 | CDC14B Knockout cell line (HEK293) | Human | CDC14B | 1:3~1:6 | Negative | Online Inquiry |
KO34055 | CDC14B Knockout cell line (A549) | Human | CDC14B | 1:3~1:4 | Negative | Online Inquiry |
CDC14B Gene Knockout Cell Lines are specialized cellular models created through the targeted disruption of the CDC14B gene, which plays a crucial role in cell cycle regulation and endogenous processes such as mitotic exit and DNA damage response. By utilizing gene editing techniques, such as CRISPR/Cas9, these knockout cell lines provide researchers with a unique opportunity to investigate the biological pathways influenced by CDC14B and assess the consequences of its loss of function.
The primary mechanism of these cell lines revolves around the absence of CDC14B, allowing scientists to explore how this deficiency affects cell proliferation, apoptosis, and response to genotoxic stress. The remarkable precision of gene knockout technology enables researchers to create a controlled environment where the functional implications of CDC14B can be methodically unraveled. This is particularly significant for studies investigating tumorigenesis, as aberrations in CDC14B expression have been implicated in various cancers.
From a scientific perspective, CDC14B Gene Knockout Cell Lines serve invaluable applications in both research and clinical settings. They can be utilized to screen for potential therapeutic compounds, analyze cell cycle checkpoints, and validate biomarker candidates for diagnostic purposes. Their versatility and potential to model disease mechanisms provide a wealth of knowledge for basic and applied biological research.
What sets our CDC14B Gene Knockout Cell Lines apart from alternatives is their unparalleled specificity and reliability. Each cell line undergoes rigorous validation processes, ensuring consistent performance and reproducibility in experimental setups. Additionally, our comprehensive technical support helps users maximize the utility of these models.
For researchers and clinicians alike, these cell lines are an essential tool that bridges the gap between basic research and therapeutic development. Our commitment to advancing scientific understanding through high-quality biological products is exemplified by our expertise in producing genetically engineered cell lines that empower the scientific community. By investing in these models, you enable a deeper insight into cellular dynamics and therapeutic strategies that can potentially transform the treatment landscape for diseases associated with CDC14B dysregulation.
Please note that all services are for research use only. Not intended for any clinical use.
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