Gene: CD320
Official Full Name: CD320 moleculeprovided by HGNC
Gene Summary: This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and is involved in B-cell proliferation and immunoglobulin secretion. Mutations in this gene are associated with methylmalonic aciduria. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO22718 | CD320 Knockout cell line (HeLa) | Human | CD320 | 1:3~1:6 | Negative | Online Inquiry |
KO22719 | CD320 Knockout cell line (HCT 116) | Human | CD320 | 1:2~1:4 | Negative | Online Inquiry |
KO22720 | CD320 Knockout cell line (HEK293) | Human | CD320 | 1:3~1:6 | Negative | Online Inquiry |
KO22721 | CD320 Knockout cell line (A549) | Human | CD320 | 1:3~1:4 | Negative | Online Inquiry |
CD320 Gene Knockout Cell Lines are specifically engineered cell models designed to study the functionality of the CD320 gene, which encodes for a receptor known to play crucial roles in folate transport and cellular metabolism. These knockout cell lines have been meticulously developed using CRISPR/Cas9 technology to enable targeted gene disruption, effectively creating a cellular environment where the CD320 gene is nonfunctional. This allows researchers to investigate the biochemical and physiological impacts that the absence of CD320 has on cellular functions, including its influence on cell proliferation, differentiation, and nutrient uptake.
The primary function of these knockout cell lines lies in elucidating the molecular mechanisms underlying various health conditions associated with folate metabolism, such as neural tube defects and certain types of cancers. By impairing CD320 expression, researchers can observe alterations in cell behavior and signaling pathways, thereby enhancing our understanding of nutrient transport mechanisms and their implications in disease pathology.
Scientifically, CD320 Gene Knockout Cell Lines hold significant importance in both basic and translational research. In clinical settings, these models provide invaluable insights into patient stratification and therapeutic targets, particularly in diseases linked to aberrant folate metabolism. Their utility in drug development is paramount, as they can be employed for screening potential compounds that may restore normal cellular functions disrupted by CD320 deficiency.
Compared to alternative models, our CD320 Gene Knockout Cell Lines stand out due to their high specificity and reliability, ensuring reproducible results that are critical for rigorous scientific inquiry. Furthermore, they eliminate the residual activity seen in other knockdown approaches, allowing for a clearer interpretation of gene function.
For researchers and clinicians, the value of these cell lines extends beyond mere experimental tools; they represent a gateway to advancing our understanding of complex biological systems. By integrating these resources into your research, you can enhance the depth and breadth of your studies, potentially leading to novel therapeutic strategies.
Our company prides itself on expertise in the development of high-quality biological products tailored for cutting-edge research applications. With a commitment to innovation and reliability, we stand ready to support the scientific community in uncovering the mysteries of human health and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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