Gene: CCL4L1
Official Full Name: C-C motif chemokine ligand 4 like 1provided by HGNC
Gene Summary: This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO18917 | CCL4L1 Knockout cell line (HeLa) | Human | CCL4L1 | 1:3~1:6 | Negative | Online Inquiry |
KO18918 | CCL4L1 Knockout cell line (HCT 116) | Human | CCL4L1 | 1:2~1:4 | Negative | Online Inquiry |
KO18919 | CCL4L1 Knockout cell line (HEK293) | Human | CCL4L1 | 1:3~1:6 | Negative | Online Inquiry |
KO18920 | CCL4L1 Knockout cell line (A549) | Human | CCL4L1 | 1:3~1:4 | Negative | Online Inquiry |
CCL4L1 Gene Knockout Cell Lines are genetically engineered cellular models designed to lack the CCL4L1 gene, which encodes a chemokine vital for immune response and cellular signaling. These knockout cell lines serve as powerful tools to study the physiological and pathological roles of CCL4L1 in various biological processes, including inflammation, cancer progression, and immune system modulation. By integrating CRISPR/Cas9 technology or other gene editing techniques, these cell lines enable researchers to investigate the direct effects of CCL4L1 deficiency on cellular behavior, migration, and the tumor microenvironment.
The key functionality of these knockout cell lines lies in their ability to mimic human disease states by accurately reflecting the consequences of CCL4L1 gene deletion. This provides a detailed understanding of how alterations in chemokine signaling impact immune cell recruitment, cytokine production, and overall cellular dynamics. Such insights are critical in both basic research and translational studies, where understanding immune cell interactions can lead to novel therapeutic approaches for diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.
The scientific importance of CCL4L1 Gene Knockout Cell Lines is further underscored by their application in drug discovery and development processes, allowing researchers to screen for potential therapeutics that target chemokine pathways. Compared to standard cell lines, genetically modified models that incorporate specific gene knockouts offer a higher degree of specificity and relevance to human physiology, enabling more accurate modeling of disease states and drug responses.
What sets our CCL4L1 Gene Knockout Cell Lines apart from alternatives is the rigorous quality control and validation processes employed during their development, ensuring reproducibility and reliability in experimental outcomes. Researchers, clinicians, and pharmaceutical companies will find immense value in these models, as they provide crucial data that can bridge the gap between laboratory research and clinical application.
With extensive expertise in the field of genetic engineering and a commitment to innovation, our company is dedicated to providing high-quality biological products that empower researchers and clinicians to advance their work in understanding and treating complex diseases.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.