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CCDC88C Knockout Cell Lines

Gene: CCDC88C

Official Full Name: coiled-coil domain containing 88Cprovided by HGNC

Gene Summary: This gene encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the dishevelled protein and is a negative regulator of the Wnt signalling pathway. The protein encoded by this gene has a PDZ-domain binding motif in its C-terminus with which it interacts with the dishevelled protein. Dishevelled is a scaffold protein involved in the regulation of the Wnt signaling pathway. The Wnt signaling pathway plays an important role in embryonic development, tissue maintenance, and cancer progression. Mutations in this gene cause autosomal recessive, primary non-syndromic congenital hydrocephalus; a condition characterized by excessive accumulation of cerebrospinal fluid in the ventricles of the brain. [provided by RefSeq, Jan 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18984 CCDC88C Knockout cell line (HeLa) Human CCDC88C 1:3~1:6 Negative Online Inquiry
KO18985 CCDC88C Knockout cell line (HCT 116) Human CCDC88C 1:2~1:4 Negative Online Inquiry
KO18986 CCDC88C Knockout cell line (HEK293) Human CCDC88C 1:3~1:6 Negative Online Inquiry
KO18987 CCDC88C Knockout cell line (A549) Human CCDC88C 1:3~1:4 Negative Online Inquiry

Background

CCDC88C Gene Knockout Cell Lines are a valuable, genetically engineered tool designed to facilitate the study of the CCDC88C gene's function and its role in various biological processes. CCDC88C, also known as RhoGAP, encodes a protein that is involved in actin cytoskeletal organization, cell migration, and signal transduction pathways. These cell lines enable researchers to investigate the gene's specific contributions to cellular functions by providing a model system where the gene's expression has been completely disrupted.

The key mechanism behind our CCDC88C knockout cell lines involves the targeted disruption of the CCDC88C gene using advanced CRISPR-Cas9 gene-editing technology. This precise approach allows for the generation of stable cell lines that lack CCDC88C expression, making them instrumental for elucidating the gene's functional pathways and interactions with other proteins. Researchers can utilize these cell lines for a wide range of applications, including cancer biology, neurobiology, and developmental studies, thereby advancing our understanding of cellular dynamics under conditions of altered gene expression.

One of the major advantages of CCDC88C Gene Knockout Cell Lines is their reliability and reproducibility compared to traditional methods of gene silencing, such as RNA interference, which can produce variable results. Furthermore, these knockout lines provide a robust foundation for high-throughput screening and drug discovery initiatives, offering a distinct edge over alternative models that may still express residual levels of the target gene.

The scientific importance of these cell lines cannot be overstated, as they serve as a critical resource for researchers and clinicians alike. They empower users to explore therapeutic targets and validate hypotheses surrounding cell signaling and disease mechanisms, ultimately enhancing the translational potential of their findings.

At [Your Company Name], we specialize in the development of innovative biological products and cell line models, leveraging our expertise to provide researchers with the tools they need to push the boundaries of scientific discovery. Our commitment to quality and precision ensures that our CCDC88C Gene Knockout Cell Lines meet the highest standards for use in advanced research settings.

Please note that all services are for research use only. Not intended for any clinical use.

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