Gene: CCDC39
Official Full Name: coiled-coil domain 39 molecular ruler complex subunitprovided by HGNC
Gene Summary: The protein encoded by this gene is involved in the motility of cilia and flagella. The encoded protein is essential for the assembly of dynein regulatory and inner dynein arm complexes, which regulate ciliary beat. Defects in this gene are a cause of primary ciliary dyskinesia type 14 (CILD14). [provided by RefSeq, Jul 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20273 | CCDC39 Knockout cell line (HCT 116) | Human | CCDC39 | 1:2~1:4 | Negative | Online Inquiry |
KO20274 | CCDC39 Knockout cell line (HEK293) | Human | CCDC39 | 1:3~1:6 | Negative | Online Inquiry |
CCDC39 Gene Knockout Cell Lines are genetically modified cell lines that have undergone targeted gene editing to disrupt the CCDC39 gene, which is crucial for the assembly and function of cilia. These specialized eukaryotic structures play pivotal roles in cell signaling, motility, and sensory functions. By employing CRISPR/Cas9 technology, CCDC39 is specifically knocked out, effectively allowing researchers to investigate the gene's function in cellular processes and its role in various diseases, including some ciliopathies.
The primary function of these knockout cell lines lies in their ability to facilitate the study of ciliary assembly, function, and associated signaling pathways. Researchers can utilize CCDC39 knockout cells to explore the consequences of disrupted cilia on cellular behavior and pathology, providing valuable insights into mechanisms of diseases where ciliary dysfunction is implicated.
Scientifically, CCDC39 Gene Knockout Cell Lines contribute critically to the fields of developmental biology and genetics, offering a robust model for mimicking human disease states. Their application includes drug screening, gene function analysis, and the elucidation of pathways implicated in conditions such as kidney disease and respiratory disorders.
What sets these cell lines apart from conventional models is their specificity and reliability in mimicking human physiological conditions. Unlike other models, they enable precise examination of the CCDC39 gene's role, thus providing a more nuanced understanding of how genetic changes impact cellular function.
CCDC39 Gene Knockout Cell Lines offer unparalleled opportunities for researchers and clinicians aiming to develop targeted therapies or investigate fundamental biological questions. The precision of these models allows for both high-throughput screening and detailed mechanistic studies, making them indispensable tools in modern biomedical research.
Our company's expertise in gene editing technologies ensures that each cell line is developed with rigor and precision. We are committed to providing high-quality biological products that facilitate advancements in understanding human health and disease, thus empowering researchers to make impactful discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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