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CCDC32 Knockout Cell Lines

Gene: CCDC32

Official Full Name: coiled-coil domain containing 32provided by HGNC

Gene Summary: Involved in head development and regulation of clathrin-dependent endocytosis. Part of clathrin-coated pit. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO23750 CCDC32 Knockout cell line (HeLa) Human CCDC32 1:3~1:6 Negative Online Inquiry
KO23751 CCDC32 Knockout cell line (HCT 116) Human CCDC32 1:2~1:4 Negative Online Inquiry
KO23752 CCDC32 Knockout cell line (HEK293) Human CCDC32 1:3~1:6 Negative Online Inquiry
KO23753 CCDC32 Knockout cell line (A549) Human CCDC32 1:3~1:4 Negative Online Inquiry

Background

CCDC32 Gene Knockout Cell Lines are genetically engineered cellular models designed to specifically disrupt the expression of the CCDC32 gene, known for its involvement in cytoskeletal organization and cellular signaling pathways. By utilizing CRISPR/Cas9 technology, these knockout cell lines allow for precise genome editing, enabling researchers to study the phenotypic effects of CCDC32 loss and gain insight into its functional roles in cellular processes such as cell adhesion, migration, and proliferation.

The key mechanism of action for these cell lines lies in the targeted introduction of double-strand breaks in the DNA at the CCDC32 locus, which are repaired by non-homologous end joining, leading to frameshift mutations. This results in a functional knockout of the gene, thus providing researchers with a robust tool to dissect the biological impacts of CCDC32 disruptions.

Scientifically, CCDC32 gene knockout cell lines are essential for elucidating the underlying mechanisms of diseases in which CCDC32 is implicated, such as some forms of cancer and metabolic disorders. In clinical research, they offer a means to identify potential therapeutic targets and biomarkers, thus paving the way for advancements in precision medicine.

One of the unique advantages of our CCDC32 Gene Knockout Cell Lines is their specificity and reliability compared to traditional methods, such as RNA interference, which may provide off-target effects or incomplete knockdown. With our cell lines, researchers can achieve a truly knockout phenotype, enabling more accurate interpretations of experimental data. Additionally, these cell lines are thoroughly validated for consistency in genetic modification, enhancing reproducibility across experiments.

For researchers and clinicians focused on genetic and cellular studies, these knockout cell lines represent an invaluable resource. They empower the scientific community to probe deeper into the molecular mechanisms governing various pathologies and enhance the development of innovative therapeutic strategies.

Our company is committed to pushing the boundaries of biological research by offering high-quality, rigorously validated products. With a focus on advanced genetic tools and a robust support system, we enable scientists to accelerate their discoveries and contribute to the advancement of biomedical science.

Please note that all services are for research use only. Not intended for any clinical use.

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