Gene: CBR1
Official Full Name: carbonyl reductase 1provided by HGNC
Gene Summary: The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38663 | CBR1 Knockout cell line (HeLa) | Human | CBR1 | 1:3~1:6 | Negative | Online Inquiry |
KO38664 | CBR1 Knockout cell line (HEK293) | Human | CBR1 | 1:3~1:6 | Negative | Online Inquiry |
KO38665 | CBR1 Knockout cell line (A549) | Human | CBR1 | 1:3~1:4 | Negative | Online Inquiry |
CBR1 Gene Knockout Cell Lines are an advanced biological research tool specifically engineered to study the function of the carbonyl reductase 1 (CBR1) gene. This gene, implicated in various metabolic processes and drug metabolism, plays a crucial role in pharmacogenomics and the conversion of carbonyl compounds. By creating knockout models, researchers can elucidate the biological pathways influenced by CBR1, providing insight into its contributions to cellular processes, disease mechanisms, and potential therapeutic interventions.
The key function of these cell lines lies in their disruption of the CBR1 gene, allowing scientists to investigate the resultant phenotypes and biochemical processes that occur in its absence. This is achieved through CRISPR-Cas9 technology, which offers precise editing capabilities to delete or modify genetic sequences. Researchers can, therefore, explore the impact of CBR1 on enzyme activity, oxidative stress response, and drug interactions in vitro, facilitating a more profound understanding of its physiological relevance.
From a scientific perspective, CBR1 Gene Knockout Cell Lines are invaluable in both basic and applied research settings. They enable the validation of drug detoxification pathways, investigation of metabolic disorders, and studies into cancer biology where metabolic reprogramming occurs. This functionality is vital for developing targeted therapies and understanding interindividual variability in drug responses.
What sets these cell lines apart from traditional knockout models is their high efficiency and specificity, coupled with the comprehensive support for experimental applications, including cytokine assays and metabolic profiling. Additionally, they are characterized by rigorous quality control and consistent performance across experimental setups, thereby enhancing reproducibility in research findings.
By investing in CBR1 Gene Knockout Cell Lines, researchers and clinicians gain a significant edge in their studies. The ability to investigate the intricate roles of CBR1 not only advances scientific knowledge but also drives innovation in the development of future therapeutics tailored to individual genetic makeups.
At our company, we pride ourselves on our commitment to providing high-quality biotechnological solutions backed by rigorous scientific validation and an experienced team of professionals dedicated to supporting the research community. Our offerings are designed with the needs of scientists and clinicians in mind, ensuring they have access to the best tools for advancing their work.
Please note that all services are for research use only. Not intended for any clinical use.
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