Gene: CAV2
Official Full Name: caveolin 2provided by HGNC
Gene Summary: The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01463 | CAV2 Knockout cell line (PANC-1) | Human | CAV2 | 1:2-1:4 | Negative | Online Inquiry |
KO19053 | CAV2 Knockout cell line (HeLa) | Human | CAV2 | 1:3~1:6 | Negative | Online Inquiry |
KO19054 | CAV2 Knockout cell line (HCT 116) | Human | CAV2 | 1:2~1:4 | Negative | Online Inquiry |
KO19055 | CAV2 Knockout cell line (HEK293) | Human | CAV2 | 1:3~1:6 | Negative | Online Inquiry |
KO19056 | CAV2 Knockout cell line (A549) | Human | CAV2 | 1:3~1:4 | Negative | Online Inquiry |
CAV2 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to study the role and function of the caveolin-2 (CAV2) protein in various biological processes. By applying CRISPR/Cas9 gene-editing technology, these cell lines have been meticulously developed to create a complete knockout of the CAV2 gene, allowing researchers to investigate the downstream effects on cellular signaling, lipid metabolism, and cellular architecture.
The primary mechanism of action involves the absence of the CAV2 protein, which plays an integral role in the formation of caveolae—small invaginations in the plasma membrane that are essential in cholesterol transport and various signaling pathways. By utilizing these knockout cell lines, researchers can elucidate the contributions of CAV2 to cardiovascular functions, adipocyte biology, and diseases such as cancer and diabetes. This makes CAV2 Gene Knockout Cell Lines a vital tool for advancing our understanding of the molecular underpinnings associated with these conditions.
The scientific importance of these cell lines extends to both basic and translational research, facilitating the development of potential therapeutic strategies targeting CAV2-related pathways. Compared to traditional cell lines that may express non-specific variants of the CAV2 gene, these knockout models provide a clearer, more precise understanding of CAV2’s physiological roles, leading to more reliable experimental results.
For researchers and clinicians, the CAV2 Gene Knockout Cell Lines represent a significant advancement in creating novel experimental models, thus enhancing the ability to tailor studies to specific hypotheses. The product is valuable not only for academic institutions but also for biotechnology and pharmaceutical companies seeking innovative approaches to drug development and disease modeling.
With a proven track record in genetic engineering technologies, our company is committed to equipping scientists with high-quality, reliable tools that empower groundbreaking discoveries in molecular biology and medicine. Our expertise assures customers that our gene knockout cell lines meet rigorous scientific standards, positioning them as indispensable resources in the expanding field of cellular and molecular research.
Please note that all services are for research use only. Not intended for any clinical use.
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