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BTRC Knockout Cell Lines

Gene: BTRC

Official Full Name: beta-transducin repeat containing E3 ubiquitin protein ligaseprovided by HGNC

Gene Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00172 BTRC Knockout cell line (A549) Human BTRC 1:3~1:4 Negative Online Inquiry
KO11827 BTRC Knockout cell line (HeLa) Human BTRC 1:3~1:6 Negative Online Inquiry
KO11828 BTRC Knockout cell line (HCT 116) Human BTRC 1:2~1:4 Negative Online Inquiry
KO11829 BTRC Knockout cell line (HEK293) Human BTRC 1:3~1:6 Negative Online Inquiry

Background

BTRC Gene Knockout Cell Lines are genetically engineered cell lines that have been meticulously crafted to harbor specific deletions in the BTRC gene, which encodes for an E3 ubiquitin ligase involved in various cellular processes, including protein degradation and apoptosis regulation. These cell lines serve as invaluable tools for researchers seeking to decipher the biological roles of the BTRC gene and its implications in disease mechanisms, particularly in cancer and immune responses.

The primary function of these knockout cell lines lies in their ability to model specific genetic deficiencies. By eliminating the BTRC gene, scientists can observe the resultant phenotypic and molecular changes, unraveling insights into signaling pathways and cellular processes that the gene influences. The mechanistic understanding gained from these studies can lead to advancements in therapeutic approaches, allowing researchers to target these pathways for drug development.

Scientific applications of the BTRC Gene Knockout Cell Lines extend from basic research, where they illuminate fundamental biological questions, to clinical settings that explore how BTRC gene alterations are associated with pathological conditions. Their use can facilitate high-throughput screens for novel compounds or efficacy studies of therapeutic candidates.

What sets BTRC Gene Knockout Cell Lines apart from other models is their precision and reliability. These cell lines undergo rigorous validation to ensure consistency in genetic knockout efficacy and retention of physiological characteristics, thereby providing a solid foundation for reproducible results. By utilizing these cell lines, researchers benefit from an efficient pathway to advance their studies without the variability presented by less controlled experimental platforms.

The value of BTRC Gene Knockout Cell Lines to researchers and clinicians cannot be overstated. They offer a streamlined approach to investigating gene function and related cellular phenomena, thus accelerating research timelines and enhancing the potential for impactful scientific discoveries. Our company prides itself on its expertise in developing high-quality biological products tailored to meet the evolving needs of the scientific community, ensuring that researchers have access to reliable and cutting-edge tools to enhance their work.

Please note that all services are for research use only. Not intended for any clinical use.

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