Gene: BRPF1
Official Full Name: bromodomain and PHD finger containing 1provided by HGNC
Gene Summary: This gene encodes a bromodomain, PHD finger and chromo/Tudor-related Pro-Trp-Trp-Pro (PWWP) domain containing protein. The encoded protein is a component of the MOZ/MORF histone acetyltransferase complexes which function as a transcriptional regulators. This protein binds to the catalytic MYST domains of the MOZ and MORF proteins and may play a role in stimulating acetyltransferase and transcriptional activity of the complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04506 | BRPF1 Knockout cell line (HeLa) | Human | BRPF1 | 1:3~1:6 | Negative | Online Inquiry |
KO04507 | BRPF1 Knockout cell line (HCT 116) | Human | BRPF1 | 1:2~1:4 | Negative | Online Inquiry |
KO04508 | BRPF1 Knockout cell line (HEK293) | Human | BRPF1 | 1:3~1:6 | Negative | Online Inquiry |
KO04509 | BRPF1 Knockout cell line (A549) | Human | BRPF1 | 1:3~1:4 | Negative | Online Inquiry |
BRPF1 Gene Knockout Cell Lines are genetically engineered cell lines designed to specifically disrupt the BRPF1 gene, which encodes for a crucial component involved in chromatin regulation and transcriptional control. These cell lines have been developed using advanced CRISPR-Cas9 technology, ensuring precise genetic modification and reproducibility. By knocking out the BRPF1 gene, researchers can investigate the subsequent effects on cellular functions, gene expression patterns, and overall cellular behavior, providing valuable insights into the biological roles of this gene in various physiological and pathological contexts.
The key function of the BRPF1 gene knockout cell lines lies in their utility as powerful tools for studying the implications of BRPF1 deficiency. BRPF1 is known to play a role in histone modification and chromatin remodeling, processes integral to gene regulation. By employing these knockout cell lines, scientists can observe alterations in cell proliferation, differentiation, and response to external stimuli, facilitating a deeper understanding of disorders linked to chromatin dysregulation, such as cancer and neurodegenerative diseases.
The scientific importance of BRPF1 Gene Knockout Cell Lines extends into both basic research and clinical applications. They serve as a vital resource for elucidating the functional genomics of chromatin-related pathways and can be pivotal in drug discovery efforts aimed at targeting epigenetic modifications. Moreover, these cell lines can aid in the development of personalized medicine strategies by allowing for the exploration of gene-environment interactions and therapeutic responses.
Compared to other genetic manipulation methods, such as traditional gene silencing techniques or overexpression systems, BRPF1 Gene Knockout Cell Lines offer the unique advantage of permanently disrupting the gene of interest. This permanence facilitates long-term studies and reduces variability associated with transient knockdown approaches. Additionally, the high specificity of CRISPR technology minimizes off-target effects, ensuring reliable results that maintain the integrity of the experimental design.
For researchers and clinicians focused on understanding the complexities of gene function and its implications in disease, BRPF1 Gene Knockout Cell Lines represent an invaluable asset. Their application not only enhances basic scientific inquiries but also informs potential therapeutic interventions that could arise from a deeper understanding of the BRPF1-associated pathways.
As a leader in the field of genetic research products, our company is committed to providing high-quality, rigorously validated biological tools that empower the scientific community to advance their research endeavors. With our extensive expertise and continual innovation, we strive to support groundbreaking discoveries across various biological disciplines.
Please note that all services are for research use only. Not intended for any clinical use.
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