Gene: BOD1
Official Full Name: biorientation of chromosomes in cell division 1provided by HGNC
Gene Summary: Enables protein phosphatase 2A binding activity and protein phosphatase inhibitor activity. Involved in mitotic sister chromatid biorientation; mitotic sister chromatid cohesion, centromeric; and protein localization to chromosome, centromeric region. Located in centrosome; spindle microtubule; and spindle pole. Part of Set1C/COMPASS complex and outer kinetochore. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO23521 | BOD1 Knockout cell line (HeLa) | Human | BOD1 | 1:3~1:6 | Negative | Online Inquiry |
KO23522 | BOD1 Knockout cell line (HCT 116) | Human | BOD1 | 1:2~1:4 | Negative | Online Inquiry |
KO23523 | BOD1 Knockout cell line (HEK293) | Human | BOD1 | 1:3~1:6 | Negative | Online Inquiry |
KO23524 | BOD1 Knockout cell line (A549) | Human | BOD1 | 1:3~1:4 | Negative | Online Inquiry |
BOD1 Gene Knockout Cell Lines are sophisticated biological tools engineered for the precise study of the BOD1 (Biorientation of Chromosomes in Cell division 1) gene, a critical regulator in mitotic processes. These cell lines have been meticulously created using CRISPR-Cas9 technology to facilitate the complete deletion of BOD1, enabling researchers to investigate the gene's role in chromosome segregation and stability during cell division.
The primary function of BOD1 gene knockout cell lines is to elucidate the molecular pathways influenced by BOD1 and its involvement in mitotic fidelity. By removing the gene, these cell lines serve as a model to assess the consequences of BOD1 loss on cellular behavior, mitotic spindle formation, and chromosomal aberrations. Furthermore, experiments utilizing these cell lines can reveal insights into the mechanisms of tumorigenesis, given the BOD1 gene's association with cancer cell proliferation and chromosomal instability.
The scientific importance of BOD1 gene knockout cell lines extends beyond basic research, providing invaluable applications in cancer biology, therapeutic screening, and drug discovery. They present a platform for testing novel pharmacological interventions aimed at correcting the dysregulation seen in BOD1-deficient cells, thereby accelerating the transition from bench to bedside.
Compared to traditional approaches, such as RNA interference or overexpression systems, BOD1 gene knockout cell lines offer unparalleled specificity and permanence in the ablation of target genes. This leads to more reliable and reproducible outcomes, making them a superior choice for researchers focused on genetic manipulation.
Ultimately, BOD1 Gene Knockout Cell Lines represent a cutting-edge resource for researchers and clinicians seeking to deepen their understanding of cell cycle regulation and its implications in disease. Our company prides itself on its advanced genetic engineering capabilities and a proven track record in providing high-quality biological products tailored to meet the rigorous demands of life science research.
Please note that all services are for research use only. Not intended for any clinical use.
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