Gene: BMPR1B
Official Full Name: bone morphogenetic protein receptor type 1Bprovided by HGNC
Gene Summary: This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11572 | BMPR1B Knockout cell line (HeLa) | Human | BMPR1B | 1:3~1:6 | Negative | Online Inquiry |
KO11573 | BMPR1B Knockout cell line (HEK293) | Human | BMPR1B | 1:3~1:6 | Negative | Online Inquiry |
KO11574 | BMPR1B Knockout cell line (A549) | Human | BMPR1B | 1:3~1:4 | Negative | Online Inquiry |
BMPR1B Gene Knockout Cell Lines are engineered cellular models designed to facilitate the study of bone morphogenetic protein (BMP) signaling pathways, with a focus on the BMP receptor type 1B (BMPR1B). These cell lines are created using advanced CRISPR-Cas9 gene-editing technology, resulting in precise deletions of the BMPR1B gene, thereby allowing researchers to investigate the role of this receptor in cellular processes such as differentiation, proliferation, and apoptosis.
The key function of BMPR1B is to mediate various biological responses, particularly those associated with bone and cartilage formation, making these knockout cell lines essential in elucidating BMP signaling's contributions to these processes. By attenuating or removing BMPR1B expression, researchers can observe altered cellular behaviors, leading to insights into conditions like osteoporosis, osteoarthritis, and other bone-related disorders. This makes the BMPR1B Gene Knockout Cell Lines invaluable for academic research as well as translational studies aiming to bridge basic science and clinical applications.
One notable advantage of using our BMPR1B knockout cell lines is their ability to provide clear and reproducible data, crucial for experimental validity. Unlike traditional methods, these knockout models offer a higher degree of specificity and control over gene expression, ensuring that the observed phenotypes are directly attributable to the loss of BMPR1B function. Furthermore, our cell lines are readily adaptable for various assays, including drug screening, gene expression analysis, and mechanistic investigations.
The value of BMPR1B Gene Knockout Cell Lines to researchers and clinicians cannot be overstated, as they provide critical tools for understanding BMP signaling in both health and disease states. By employing these cell lines, users can accelerate their research into therapeutic targets and strategies, thereby supporting advancements in regenerative medicine and orthopedic research.
At [Company Name], we are committed to delivering high-quality biological products and innovative solutions. Our expertise in genetic engineering and cellular biology ensures that our BMPR1B Gene Knockout Cell Lines will enhance your research capabilities and contribute to significant scientific breakthroughs.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.