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BMAL2 Knockout Cell Lines

Gene: BMAL2

Official Full Name: basic helix-loop-helix ARNT like 2provided by HGNC

Gene Summary: This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04492 BMAL2 Knockout cell line (HeLa) Human BMAL2 1:3~1:6 Negative Online Inquiry
KO04493 BMAL2 Knockout cell line (HCT 116) Human BMAL2 1:2~1:4 Negative Online Inquiry
KO04494 BMAL2 Knockout cell line (HEK293) Human BMAL2 1:3~1:6 Negative Online Inquiry
KO04495 BMAL2 Knockout cell line (A549) Human BMAL2 1:3~1:4 Negative Online Inquiry

Background

BMAL2 Gene Knockout Cell Lines are genetically engineered cell lines that have undergone targeted disruption of the BMAL2 gene, which encodes a critical protein involved in the regulation of circadian rhythms and various metabolic processes. By removing the functional gene, these cell lines serve as invaluable tools for researchers investigating the underlying mechanisms of circadian biology, metabolic disorders, and related pathologies. These cell lines facilitate study into how BMAL2 contributes to cellular functioning, gene expression patterns, and overall physiological homeostasis.

The core mechanism of BMAL2 Gene Knockout Cell Lines lies in their ability to mimic the absence of BMAL2 and its downstream effects on cellular processes. Researchers can utilize these lines to elucidate the impact of BMAL2 on rhythmic transcriptional regulation, metabolism, and response to environmental cues. The unique properties these cells exhibit, such as altered cell cycle regulation and metabolic activity, present significant opportunities for research in chronobiology, cancer biology, and metabolic research.

The scientific importance of these cell lines is underscored by their applicability in both fundamental research and clinical assessment. Studying BMAL2 deficiency can lead to insights into sleep disorders, obesity, diabetes, and other metabolic syndromes. Moreover, these cell lines offer a straightforward platform for drug development and screening, particularly for compounds that may influence circadian-related pathways.

What sets our BMAL2 Gene Knockout Cell Lines apart from alternatives is their high specificity and reproducibility, underpinned by advanced CRISPR/Cas9 technology. This ensures precise gene editing and minimizes off-target effects, providing researchers with reliable data. Additionally, our cell lines come with detailed characterization and extensive support documentation, streamlining their integration into various research protocols.

Investing in BMAL2 Gene Knockout Cell Lines not only enhances the quality of research but also accelerates discovery in critical areas that affect global health. Our company, with expertise in cellular and molecular biology, is dedicated to delivering innovative biological products that empower researchers and clinicians in their quest for scientific advancements.

Please note that all services are for research use only. Not intended for any clinical use.

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