Gene: BCLAF1
Official Full Name: BCL2 associated transcription factor 1provided by HGNC
Gene Summary: This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32784 | BCLAF1 Knockout cell line (HeLa) | Human | BCLAF1 | 1:3~1:6 | Negative | Online Inquiry |
KO32785 | BCLAF1 Knockout cell line (HCT 116) | Human | BCLAF1 | 1:2~1:4 | Negative | Online Inquiry |
KO32786 | BCLAF1 Knockout cell line (HEK293) | Human | BCLAF1 | 1:3~1:6 | Negative | Online Inquiry |
BCLAF1 Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to disrupt the BCLAF1 gene, which encodes a protein involved in critical cellular processes, including apoptosis regulation and stress responses. By utilizing CRISPR-Cas9 technology or similar gene-editing techniques, these cell lines allow researchers to investigate the functional implications of BCLAF1 deficiency in various physiological and pathological contexts, facilitating a greater understanding of cellular behavior under different conditions.
The primary mechanism of action involves the complete knockout of the BCLAF1 gene, which leads to significant alterations in cellular pathways, including those related to cell survival and immune responses. As BCLAF1 interacts with key regulators of apoptosis, its knockout can result in altered responses to genomic stress and apoptotic stimuli, making these cell lines invaluable for exploring cancer biology, neurodegenerative diseases, and other disorders where apoptosis plays a crucial role.
These knockout cell lines hold substantial scientific importance in both research and clinical applications. They serve as powerful tools for studying the role of BCLAF1 in disease models, enabling drug discovery efforts and mechanistic studies that can lead to novel therapeutic strategies. Researchers can replicate disease states more accurately, enhancing the predictive validity of their findings in translational research.
What sets BCLAF1 Gene Knockout Cell Lines apart from similar products is their ease of use and application across various experimental frameworks. Our cell lines are rigorously characterized, ensuring consistent results and user confidence. Coupled with comprehensive support and detailed protocol guidance, users can implement these models effectively in their studies.
The value of BCLAF1 Gene Knockout Cell Lines lies in their ability to enhance research outcomes, foster innovation in therapeutic developments, and contribute to the overarching goal of advancing precision medicine. By choosing our product, researchers and clinicians align themselves with a proven leader in biological products, backed by years of expertise and a commitment to excellence.
Please note that all services are for research use only. Not intended for any clinical use.
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