Gene: BARHL2
Official Full Name: BarH like homeobox 2provided by HGNC
Gene Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including generation of neurons; positive regulation of macromolecule biosynthetic process; and regulation of axon extension. Predicted to be located in chromatin. Predicted to be active in nucleus. Implicated in oral squamous cell carcinoma. Biomarker of colorectal cancer; oral squamous cell carcinoma; and stomach cancer. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO19487 | BARHL2 Knockout cell line (HEK293) | Human | BARHL2 | 1:3~1:6 | Negative | Online Inquiry |
BARHL2 Gene Knockout Cell Lines are highly specialized cellular models designed to facilitate the study of the BARHL2 gene, which is involved in crucial developmental processes, particularly in the context of neurogenesis and retinal development. These knockout cell lines are generated using cutting-edge CRISPR-Cas9 genome editing technology, ensuring precise and efficient disruption of the BARHL2 gene for experimental applications.
The key functionality of the BARHL2 gene knockout cell lines lies in their ability to provide researchers with a controlled environment to investigate the downstream effects of BARHL2 deficiency. By eliminating the functional expression of this gene, scientists can elucidate its role in cellular pathways, interactions, and phenotypic alterations associated with neural and retinal tissues. Importantly, these cell lines serve as invaluable tools in understanding the molecular underpinnings of various neurodevelopmental disorders, as well as potential therapeutic targets within these pathways.
In terms of scientific importance, BARHL2 gene knockout cell lines are foundational for a wide array of applications including basic research in developmental biology, drug discovery, and regenerative medicine. The insights gleaned from studies utilizing these models can inform clinical practices and novel therapeutic strategies for conditions linked to aberrations in neuronal and retinal development.
What sets BARHL2 gene knockout cell lines apart from other models is their high specificity and the robust validation of gene editing efficiency. They exhibit a reliable knockout phenotype which enhances reproducibility in experiments, a critical factor for researchers aiming to produce high-quality data. Furthermore, these cell lines come with comprehensive support and resources, including protocols and user guides, facilitating seamless integration into research workflows.
For researchers and clinicians focusing on neurodevelopmental biology, the BARHL2 gene knockout cell lines present a compelling opportunity to advance their understanding and drive innovation in the field. With a commitment to high-quality biological products, our company stands at the forefront of providing cutting-edge tools that empower scientific discovery and enhance translational research efforts.
Please note that all services are for research use only. Not intended for any clinical use.
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