Gene: BAG2
Official Full Name: BAG cochaperone 2provided by HGNC
Gene Summary: BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00586 | BAG2 gRNA3-gRNA4 KO plasmid | BAG2 | $850 | |||
GP00588 | BAG2 gRNA1-gRNA2 KO plasmid | BAG2 | $850 | |||
KO03260 | BAG2 Knockout cell line (HeLa) | Human | BAG2 | 1:3~1:6 | Negative | Online Inquiry |
KO03261 | BAG2 Knockout cell line (HCT 116) | Human | BAG2 | 1:2~1:4 | Negative | Online Inquiry |
KO03262 | BAG2 Knockout cell line (HEK293) | Human | BAG2 | 1:3~1:6 | Negative | Online Inquiry |
KO03263 | BAG2 Knockout cell line (A549) | Human | BAG2 | 1:3~1:4 | Negative | Online Inquiry |
BAG2 Gene Knockout Cell Lines are engineered cellular models that feature the targeted disruption of the BAG2 gene, which plays a crucial role in cellular stress response and survival pathways. Using advanced CRISPR/Cas9 technology, these cell lines provide researchers the ability to study the implications of BAG2 loss in various biological contexts, including cancer biology, neurodegenerative diseases, and cellular differentiation.
The primary function of the BAG2 gene revolves around its interaction with heat shock proteins and its involvement in chaperone-mediated protein folding, influencing apoptosis and autophagy. By employing these knockout cell lines, scientists can effectively dissect the molecular mechanisms by which BAG2 modulates stress signaling, offering insights into potential therapeutic targets for diseases where BAG2 aberration plays a role.
In research and clinical settings, BAG2 Gene Knockout Cell Lines are invaluable for investigating drug responses, modeling disease phenotypes, and understanding the pathways mediating cell survival under stress. Their applications range from fundamental biology to translational research, enabling the development of novel therapeutic strategies.
Compared to traditional cell lines or non-specific gene knockouts, BAG2 Gene Knockout Cell Lines offer specificity and precision that enhance the reproducibility of experiments. Their well-characterized genetic background ensures consistent results, making them a trusted choice among researchers.
For investigators focused on the nuances of cellular responses to stress, these knockout cell lines present a unique opportunity to delve deeper into BAG2's functional roles. Our company's dedication to high-quality biological products, paired with expertise in genetic engineering, ensures that researchers receive not only reliable models but also comprehensive support throughout their experimental journey.
Please note that all services are for research use only. Not intended for any clinical use.
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