Gene: ATRX
Official Full Name: ATRX chromatin remodelerprovided by HGNC
Gene Summary: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01107 | Atrx Knockout cell line(ID8) | Mouse | Atrx | 1:3-1:4 | Negative | Online Inquiry |
KO01129 | Atrx Knockout cell line(MC38) | Mouse | Atrx | 1:2-1:4 | Negative | Online Inquiry |
KO01138 | Atrx Knockout cell line(4T1) | Mouse | Atrx | 1:3~1:4 | Negative | Online Inquiry |
ATRX Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the ATRX gene, which plays a crucial role in chromatin remodeling and gene regulation. This gene is implicated in various cellular processes, including DNA repair, transcriptional regulation, and maintaining genome stability. The knockout of ATRX allows researchers to investigate the gene's contributions to these processes by providing a model that mimics certain genetic disorders, including developmental defects and certain forms of cancer.
The primary function of these cell lines hinges on their ability to elucidate the biological roles of the ATRX gene. By utilizing CRISPR-Cas9 or other gene-editing technologies, the knockout cell lines facilitate the study of phenotypic changes resulting from the loss of ATRX function. Researchers can explore pathways involved in cellular differentiation, oncogenesis, and neurogenesis, uncovering essential insights into gene function and interactions.
In the realm of scientific research, ATRX Gene Knockout Cell Lines are invaluable tools for both basic biological studies and translational research. They are particularly crucial for understanding ATRX-related diseases and developing novel therapeutic strategies. Their application in high-throughput screening enables scientists to identify compounds that may compensate for the loss of ATRX, potentially leading to innovative treatment options for conditions linked to its dysfunction.
What sets ATRX Gene Knockout Cell Lines apart from alternative models is their specificity and reliability. Unlike other cell lines that may exhibit variable expressions of ATRX, these knockout models provide a consistent and reproducible platform for experimentation, ensuring that observed effects result solely from the deletion of the gene in question. This specificity supports high confidence in experimental outcomes, making them an essential asset for researchers focused on gene-targeted studies.
For researchers and clinicians alike, the value of these knockout cell lines is substantial. They offer not only a reliable method for dissecting the molecular mechanisms of ATRX but also pave the way for advancements in the understanding of related diseases. With a commitment to advancing scientific inquiry, our company provides high-quality biological products tailored to meet the critical needs of our customers in various fields of research and medicine. Our expertise in genetic engineering ensures that our ATRX Gene Knockout Cell Lines serve as a robust resource for your research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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