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ATP2C1 Knockout Cell Lines

Gene: ATP2C1

Official Full Name: ATPase secretory pathway Ca2+ transporting 1provided by HGNC

Gene Summary: The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03268 ATP2C1 Knockout cell line (HeLa) Human ATP2C1 1:3~1:6 Negative Online Inquiry
KO03269 ATP2C1 Knockout cell line (HCT 116) Human ATP2C1 1:2~1:4 Negative Online Inquiry
KO03270 ATP2C1 Knockout cell line (HEK293) Human ATP2C1 1:3~1:6 Negative Online Inquiry
KO03271 ATP2C1 Knockout cell line (A549) Human ATP2C1 1:3~1:4 Negative Online Inquiry

Background

ATP2C1 Gene Knockout Cell Lines are genetically engineered cell lines designed to lack the ATP2C1 gene, which encodes for a calcium pump involved in intracellular ion homeostasis. By creating these knockout cell lines, researchers can investigate the physiological and pathological roles of ATP2C1 in various biological contexts. These knockout models facilitate the examination of cellular processes that depend on calcium signaling, including muscle contraction, neurotransmitter release, and certain neurological functions.

The key mechanism of action for these cell lines involves the disruption of ATP2C1, leading to altered calcium ion levels within the cells. This disruption allows for the investigation of how reduced calcium regulation impacts cellular signaling pathways, disease progression, and cellular responses to stress. Scientists can use these models to elucidate the gene's function and its implications in conditions such as cardiomyopathies, neurological disorders, and other diseases linked to calcium dysregulation.

The scientific importance of ATP2C1 Gene Knockout Cell Lines is profound. They serve as invaluable tools in basic research, drug discovery, and toxicology studies, allowing for a deeper understanding of disease mechanisms. These cell lines present unique advantages over traditional cell models, including specific insights into gene function and the ability to observe the effects of targeted therapeutic interventions.

Moreover, researchers and clinicians can benefit significantly from the use of these knockout cell lines in high-throughput screening environments and personalized medicine approaches. Their application in models of disease can lead to the identification of novel therapeutic targets or biomarkers.

Our company prides itself on its extensive knowledge of genetic engineering and the provision of high-quality biological tools that empower scientists in their research endeavors. By offering ATP2C1 Gene Knockout Cell Lines, we help to facilitate groundbreaking discoveries that advance the field of molecular biology and contribute to improved clinical outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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