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ATP2A3 Knockout Cell Lines

Gene: ATP2A3

Official Full Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3provided by HGNC

Gene Summary: This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08122 ATP2A3 Knockout cell line (HeLa) Human ATP2A3 1:3~1:6 Negative Online Inquiry
KO08123 ATP2A3 Knockout cell line (HCT 116) Human ATP2A3 1:2~1:4 Negative Online Inquiry
KO08124 ATP2A3 Knockout cell line (HEK293) Human ATP2A3 1:3~1:6 Negative Online Inquiry
KO08125 ATP2A3 Knockout cell line (A549) Human ATP2A3 1:3~1:4 Negative Online Inquiry

Background

ATP2A3 Gene Knockout Cell Lines are a cutting-edge biological product designed for advanced research in cellular physiology and gene function. These cell lines are genetically engineered to have a specific deletion in the ATP2A3 gene, which encodes the protein Ca²⁺-ATPase 3, a critical enzyme involved in calcium homeostasis within cells. By disrupting the expression of this gene, researchers can investigate the cellular and molecular consequences of altered calcium regulation in various physiological and pathological states.

The key functionality of these cell lines lies in their ability to model conditions that mimic human diseases related to calcium dysregulation, such as certain cardiomyopathies and neurodegenerative disorders. Researchers can utilize these ATP2A3 knockout cell lines to examine how the absence of this specific ATPase influences cellular signaling pathways, apoptosis, and muscle contraction dynamics. Furthermore, the cells serve as valuable tools in drug discovery and toxicity studies, allowing scientists to assess the efficacy and safety of compounds that target calcium transport mechanisms.

The scientific importance of ATP2A3 Gene Knockout Cell Lines is evident in both research and clinical settings. They provide essential insights into the role of calcium in cellular processes, offering potential avenues for therapeutic interventions. Additionally, the use of these cell lines can accelerate the identification of new biomarkers for disease progression, improving patient care through early detection and personalized medicine approaches.

Compared to alternative models, these knockout cell lines offer unparalleled specificity in studying the ATP2A3 gene effect. Unlike traditional knockdown strategies, gene knockout provides a complete loss-of-function model, enabling more precise investigations into the role of this gene in various biological contexts.

For researchers and clinicians dedicated to understanding calcium-related pathologies, ATP2A3 Gene Knockout Cell Lines represent a significant advancement in experimental design. They support innovative research while aligning with the growing demand for targeted gene studies in modern biomedical research.

Our company specializes in the development of high-quality genetic tools and cell lines tailored for both academic and pharmaceutical research. By offering reliable and reproducible models like the ATP2A3 Gene Knockout Cell Lines, we empower the scientific community to unlock new discoveries in regenerative medicine and disease treatment.

Please note that all services are for research use only. Not intended for any clinical use.

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