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ASIC3 Knockout Cell Lines

Gene: ASIC3

Official Full Name: acid sensing ion channel subunit 3provided by HGNC

Gene Summary: This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33366 ASIC3 Knockout cell line (HeLa) Human ASIC3 1:3~1:6 Negative Online Inquiry
KO33367 ASIC3 Knockout cell line (HCT 116) Human ASIC3 1:2~1:4 Negative Online Inquiry
KO33368 ASIC3 Knockout cell line (HEK293) Human ASIC3 1:3~1:6 Negative Online Inquiry
KO33369 ASIC3 Knockout cell line (A549) Human ASIC3 1:3~1:4 Negative Online Inquiry

Background

ASIC3 Gene Knockout Cell Lines are specialized biological tools designed to study the role of the acid-sensing ion channel 3 (ASIC3) gene in various physiological and pathological processes. These cell lines have been genetically modified through targeted gene knockout techniques, rendering them incapable of expressing the ASIC3 protein. This innovation provides researchers with a crucial platform to investigate the functional implications of ASIC3, which is known to be involved in pain sensation, neuronal signaling, and a range of neurobiological disorders.

The primary function of ASIC3 Gene Knockout Cell Lines lies in their ability to facilitate experiments aimed at elucidating the biochemical pathways influenced by ASIC3. The absence of the ASIC3 ion channel allows for direct observations regarding cellular responses to changes in pH levels, neurotransmitter activity, and ion flux, enabling detailed studies in mechanisms of pain perception and neuroprotection. Additionally, these cell lines can be utilized in drug screening and development processes, particularly for analgesics and neuroprotective agents targeting ASIC-related pathways.

The scientific importance and applications of ASIC3 Gene Knockout Cell Lines are extensive, offering crucial insights in both basic and applied research. As ASIC3 is implicated in a variety of conditions such as chronic pain syndromes, ischemic injury, and anxiety disorders, understanding its function at a cellular level can translate into therapeutic advancements.

Compared to traditional cell lines, our ASIC3 Gene Knockout Cell Lines offer a unique advantage by providing a specific model to dissect the ASIC3's role in a more controlled environment. This specificity minimizes confounding factors associated with non-targeted modifications, enhancing the validity of experimental outcomes.

For researchers and clinicians, the utilization of these knockout cell lines represents an invaluable opportunity to deepen their understanding of ASIC3-related pathways, potentially leading to breakthroughs in treatment strategies for pain and related neurobiological conditions.

Our company, with years of expertise in genetic engineering and cell line development, is committed to providing high-quality biological research tools that empower the scientific community. The ASIC3 Gene Knockout Cell Lines are a testament to our dedication to advancing research in molecular biology and therapeutic development.

Please note that all services are for research use only. Not intended for any clinical use.

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