Gene: ASCC2
Official Full Name: activating signal cointegrator 1 complex subunit 2provided by HGNC
Gene Summary: Enables K63-linked polyubiquitin modification-dependent protein binding activity. Involved in regulation of DNA-templated transcription; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Located in nucleus. Part of DNA repair complex and activating signal cointegrator 1 complex. Is active in cytosolic ribosome. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00320 | ASCC2 Knockout cell line (HeLa) | Human | ASCC2 | 1:3~1:6 | Negative | Online Inquiry |
KO05043 | ASCC2 Knockout cell line (HCT 116) | Human | ASCC2 | 1:2~1:4 | Negative | Online Inquiry |
KO05044 | ASCC2 Knockout cell line (HEK293) | Human | ASCC2 | 1:3~1:6 | Negative | Online Inquiry |
KO05045 | ASCC2 Knockout cell line (A549) | Human | ASCC2 | 1:3~1:4 | Negative | Online Inquiry |
ASCC2 Gene Knockout Cell Lines are genetically engineered cellular models designed to specifically disable the ASCC2 gene, which plays a pivotal role in the regulation of cellular processes such as DNA repair, apoptosis, and cellular response to stress. By utilizing CRISPR-Cas9 technology, these knockout cell lines provide researchers with a precise tool to study the functional implications of ASCC2 loss and its effects on cellular behavior and disease states, particularly in the context of cancer biology and gene therapy.
The key mechanism behind ASCC2 Gene Knockout Cell Lines involves the targeted disruption of the ASCC2 gene, resulting in the ablation of the protein it encodes. This allows for direct investigation into the pathways affected by ASCC2, enabling scientists to elucidate its role in critical cellular functions. With these models, researchers can conduct assays to assess changes in gene expression, cellular proliferation, and response to chemotherapeutic agents, providing insights into the gene's involvement in drug resistance and therapeutic vulnerabilities.
The scientific importance of these cell lines is underscored by their applicability in both basic research and clinical studies. They serve as invaluable tools for exploring ASCC2-related pathways, which could translate into innovative therapeutic strategies for various cancers. Additionally, they can facilitate the development of novel pharmacological agents that target DNA repair mechanisms, potentially leading to improved treatment outcomes for patients.
What sets ASCC2 Gene Knockout Cell Lines apart from other models is their specificity and reliability. Unlike conventional cancer cell lines that may carry multiple genetic alterations, these knockout lines offer a clean genetic background, minimizing confounding variables. This precision allows for more accurate interpretations of experimental data, which is critical in translating findings from the lab to clinical applications.
For researchers and clinicians seeking to unravel the complexities of cancer biology or improve therapeutic strategies, ASCC2 Gene Knockout Cell Lines represent a valuable asset. Their capability to dissect the molecular underpinnings of ASCC2 function places them at the forefront of cutting-edge research.
At [Your Company Name], we pride ourselves on delivering high-quality biological research tools, backed by robust scientific expertise and commitment to innovation. Our ASCC2 Gene Knockout Cell Lines empower the research community to drive discoveries that could ultimately enhance patient care and therapeutic approaches.
Please note that all services are for research use only. Not intended for any clinical use.
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