Gene: APLP2
Official Full Name: amyloid beta precursor like protein 2provided by HGNC
Gene Summary: This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38976 | APLP2 Knockout cell line (HeLa) | Human | APLP2 | 1:3~1:6 | Negative | Online Inquiry |
KO38977 | APLP2 Knockout cell line (HCT 116) | Human | APLP2 | 1:2~1:4 | Negative | Online Inquiry |
KO38978 | APLP2 Knockout cell line (HEK293) | Human | APLP2 | 1:3~1:6 | Negative | Online Inquiry |
KO38979 | APLP2 Knockout cell line (A549) | Human | APLP2 | 1:3~1:4 | Negative | Online Inquiry |
APLP2 Gene Knockout Cell Lines are specialized biological tools created through gene editing techniques that specifically inactivate the Amyloid Precursor-Like Protein 2 (APLP2) gene. These cell lines serve as a valuable resource for investigating the functional roles of APLP2 in various biological processes, particularly in relation to neurobiology and cellular stress responses. By eliminating the expression of APLP2, researchers can study the downstream effects on cellular mechanisms, signaling pathways, and disease models, thereby enhancing the understanding of its involvement in neurodegenerative disorders, including Alzheimer's disease.
The primary function of APLP2 Gene Knockout Cell Lines lies in their ability to elucidate the contributions of APLP2 to cellular homeostasis and neurodevelopment. The knockout effect is achieved through CRISPR-Cas9 technology, which ensures precise editing and reliable cellular models for experimentation. This advanced mechanism allows researchers to perform comparative analyses between normal and APLP2-deficient cells, enabling the assessment of therapeutic targets and potential interventions.
Scientifically, the APLP2 Gene Knockout Cell Lines offer immense value in research settings by providing insight into pathological conditions where APLP2 may play critical roles, such as synaptic stability, cellular signaling, and neuronal survival. Clinically, these models have the potential to improve drug discovery efforts, as they can be employed in high-throughput screening assays to identify compounds that modify the functions associated with APLP2.
One of the distinct advantages of our APLP2 Gene Knockout Cell Lines is their standardization and reproducibility, which surpass many conventional cell models that can exhibit high variability. Additionally, our commitment to quality ensures that these cell lines are free from contamination and have been extensively characterized to support a variety of applications. The optimized growth conditions and genetic stability also make them a superior choice compared to alternative products on the market.
For researchers and clinicians focused on understanding the mechanistic basis of diseases and developing novel therapeutic strategies, APLP2 Gene Knockout Cell Lines represent a critical tool that streamlines experimental workflows and accelerates discovery. Our company, recognized for its innovation and expertise in biological products, is dedicated to empowering the scientific community with reliable and cutting-edge tools, such as these knockout cell lines, to drive advancements in biomedical research.
Please note that all services are for research use only. Not intended for any clinical use.
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