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AP1M1 Knockout Cell Lines

Gene: AP1M1

Official Full Name: adaptor related protein complex 1 subunit mu 1provided by HGNC

Gene Summary: The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33751 AP1M1 Knockout cell line (HeLa) Human AP1M1 1:3~1:6 Negative Online Inquiry
KO33752 AP1M1 Knockout cell line (HCT 116) Human AP1M1 1:2~1:4 Negative Online Inquiry
KO33753 AP1M1 Knockout cell line (HEK293) Human AP1M1 1:3~1:6 Negative Online Inquiry
KO33754 AP1M1 Knockout cell line (A549) Human AP1M1 1:3~1:4 Negative Online Inquiry

Background

AP1M1 Gene Knockout Cell Lines are precision-engineered cellular models that enable the functional study of the AP1M1 gene, a critical component in intracellular trafficking and protein sorting pathways. Utilizing powerful CRISPR-Cas9 gene-editing technologies, these cell lines specifically disable AP1M1 gene expression, allowing researchers to analyze the resultant phenotypic changes and molecular mechanisms that govern cellular processes related to endocytosis and membrane dynamics.

The key functions of these knockout cell lines stem from the role of AP1M1 in the clathrin-mediated endocytosis pathway. By impairing AP1M1, these models provide insights into how disruption of this gene affects cargo sorting and trafficking to lysosomes, hence illuminating potential pathological mechanisms in diseases such as cancer and neurodegeneration. As these cell lines are derived from widely used host cells, they are optimally suited for a range of downstream applications, including drug screening, functional assays, and pathway analysis.

In research and clinical settings, the AP1M1 Gene Knockout Cell Lines represent a significant advancement in understanding cargo trafficking and its implications in various cellular dysfunctions. Unlike standard cell lines that may introduce artifacts, our knockout models offer a targeted approach to investigating gene function, providing clarity and reliability in experimental outcomes.

Researchers and clinicians will find these cell lines invaluable as they tackle complex biological questions or test therapeutic approaches aimed at correcting trafficking-related disorders. The precision and specificity of the knockout make it an unparalleled tool in the pursuit of novel insights into gene function, enhancing overall scientific rigor.

Our company prides itself on its deep expertise in cellular biology and gene editing technologies, ensuring that our products, including AP1M1 Gene Knockout Cell Lines, uphold the highest standards of scientific integrity and innovation. With a commitment to advancing biological research, we equip scientists with the tools they need to drive discovery and improve human health.

Please note that all services are for research use only. Not intended for any clinical use.

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