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AMBRA1 Knockout Cell Lines

Gene: AMBRA1

Official Full Name: autophagy and beclin 1 regulator 1provided by HGNC

Gene Summary: Enables enzyme binding activity; protein phosphatase activator activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including macroautophagy; positive regulation of free ubiquitin chain polymerization; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in cytosol. Part of Cul4-RING E3 ubiquitin ligase complex. Is active in cytoskeleton; mitochondrion; and nucleus. Biomarker of multiple system atrophy. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20677 AMBRA1 Knockout cell line (HeLa) Human AMBRA1 1:3~1:6 Negative Online Inquiry
KO20678 AMBRA1 Knockout cell line (HCT 116) Human AMBRA1 1:2~1:4 Negative Online Inquiry
KO20679 AMBRA1 Knockout cell line (HEK293) Human AMBRA1 1:3~1:6 Negative Online Inquiry
KO20680 AMBRA1 Knockout cell line (A549) Human AMBRA1 1:3~1:4 Negative Online Inquiry

Background

AMBRA1 Gene Knockout Cell Lines are expertly engineered cellular models designed to facilitate in-depth studies of the AMBRA1 gene, which plays a critical role in autophagy, cell proliferation, and apoptosis. These knockout cell lines are created through advanced CRISPR-Cas9 gene-editing technology, allowing for precise deletion of the AMBRA1 gene, thereby enabling researchers to investigate the gene's function and its impact on various cellular processes.

The primary mechanism underlying AMBRA1's function involves its interaction with key proteins involved in the autophagic pathway, particularly those regulating the formation of autophagosomes. By utilizing these knockout cell lines, scientists can better understand the genetic and molecular mechanisms that govern autophagy and its implications in various diseases, including cancer and neurodegenerative disorders. Such insights are invaluable for the identification of potential therapeutic targets.

The scientific importance of AMBRA1 Gene Knockout Cell Lines is underscored by their wide-ranging applications in both basic and translational research. They are instrumental for studies that explore not just the pathways associated with autophagy, but also the broader implications of AMBRA1 in cellular homeostasis and disease mechanisms. Given the incidence of dysregulated autophagy in human diseases, these cell lines present a crucial tool for therapeutic development.

What sets our AMBRA1 Gene Knockout Cell Lines apart from alternatives is the exceptional specificity and reproducibility afforded by CRISPR technology, ensuring consistent and robust data generation. Additionally, our cell lines come meticulously characterized, including validation of AMBRA1 knockout efficiency and assessment of cellular markers, providing confidence in their use for various experimental applications.

For researchers and clinicians, the value of these cell lines extends beyond mere availability; they present a unique opportunity to delve into uncharted areas of cellular biology and pathophysiology. Utilizing our AMBRA1 Gene Knockout Cell Lines can catalyze groundbreaking discoveries that may lead to innovative treatments and therapies.

As a leading provider of advanced biological products, our company boasts a strong foundation in scientific expertise and rigorous quality control, ensuring that our offerings meet the high standards necessary for impactful research. Experience the transformative potential of our AMBRA1 Gene Knockout Cell Lines and elevate your research to new heights.

Please note that all services are for research use only. Not intended for any clinical use.

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