Gene: ALG10
Official Full Name: ALG10 alpha-1,2-glucosyltransferaseprovided by HGNC
Gene Summary: This gene encodes a membrane-associated protein that adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. That is, it transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. The rat protein homolog was shown to specifically modulate the gating function of the rat neuronal ether-a-go-go (EAG) potassium ion channel. [provided by RefSeq, Jan 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24476 | ALG10 Knockout cell line (HeLa) | Human | ALG10 | 1:3~1:6 | Negative | Online Inquiry |
KO24477 | ALG10 Knockout cell line (HCT 116) | Human | ALG10 | 1:2~1:4 | Negative | Online Inquiry |
KO24478 | ALG10 Knockout cell line (HEK293) | Human | ALG10 | 1:3~1:6 | Negative | Online Inquiry |
KO24479 | ALG10 Knockout cell line (A549) | Human | ALG10 | 1:3~1:4 | Negative | Online Inquiry |
ALG10 Gene Knockout Cell Lines are specifically engineered cellular models designed to study the biological functions and regulatory mechanisms of the ALG10 gene, which encodes a crucial glycosyltransferase involved in N-glycan biosynthesis. These cell lines are created through precise genome editing techniques, ensuring the complete disruption of the ALG10 gene, thereby allowing researchers to investigate the downstream effects of its absence on cellular processes, glycoprotein maturation, and various disease mechanisms.
The key functions of ALG10 revolve around its role in ensuring proper protein folding and translocation through the endoplasmic reticulum. By knocking out this gene, the cell lines provide a powerful tool for elucidating the pathways associated with glycosylation defects, which can lead to serious metabolic disorders and contribute to understanding cancer and immune responses. Researchers can utilize these knockout models to explore compensatory pathways and to validate potential therapeutic approaches targeting protein glycosylation.
The scientific importance of ALG10 Gene Knockout Cell Lines extends beyond mere exploration; they serve as vital resources in drug discovery and the development of gene therapies. With the increasing relevance of tailored medical treatments, these models enable more sophisticated assessments of treatment responses in conditions arising from glycosylation abnormalities.
One of the unique selling points of our ALG10 Gene Knockout Cell Lines is their high specificity and reliability, which stem from our advanced CRISPR-Cas9 gene-editing technology. This allows for minimal off-target effects and enhances reproducibility in research outcomes. Compared to alternative cell lines, our models are optimized for rigorous scientific inquiry, offering a more accurate reflection of human disease mechanisms.
The value of ALG10 Gene Knockout Cell Lines to researchers and clinicians cannot be overstated, as they provide crucial insights into fundamental biological processes and potential therapeutic targets. These models promote innovative approaches to tackling glycosylation-related disorders, significantly accelerating the path to novel treatments.
Our company specializes in cutting-edge cellular and molecular tools, combining extensive expertise in genetic engineering with a commitment to advancing life sciences. We strive to empower researchers with high-quality products that drive meaningful scientific advancements, making our ALG10 Gene Knockout Cell Lines an essential addition to your experimental toolkit.
Please note that all services are for research use only. Not intended for any clinical use.
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