Gene: AKAP9
Official Full Name: A-kinase anchoring protein 9provided by HGNC
Gene Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. [provided by RefSeq, Aug 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32245 | AKAP9 Knockout cell line (HeLa) | Human | AKAP9 | 1:3~1:6 | Negative | Online Inquiry |
KO32246 | AKAP9 Knockout cell line (HCT 116) | Human | AKAP9 | 1:2~1:4 | Negative | Online Inquiry |
KO32247 | AKAP9 Knockout cell line (HEK293) | Human | AKAP9 | 1:3~1:6 | Negative | Online Inquiry |
KO32248 | AKAP9 Knockout cell line (A549) | Human | AKAP9 | 1:3~1:4 | Negative | Online Inquiry |
AKAP9 Gene Knockout Cell Lines represent a powerful tool in cell biology and genetic research, designed explicitly for the study of the A-kinase anchor protein 9 (AKAP9) gene. These cell lines are genetically engineered to have a complete knockout of the AKAP9 gene, facilitating in-depth investigation into its role in cellular signaling pathways and disease mechanisms. AKAP9 is known for its critical function in anchoring protein kinase A (PKA) and other signaling molecules, thereby influencing various processes, including cell cycle regulation, cell adhesion, and the response to cellular stress.
The key mechanism through which AKAP9 Gene Knockout Cell Lines operate involves the absence of the AKAP9 protein, allowing researchers to observe the consequences of its loss. This provides valuable insights into the functional roles of AKAP9 in health and disease, particularly in cancers, where dysregulation of PKA signaling is frequently implicated. Researchers can use these cell lines to explore therapeutic targets or identify biomarkers for potential clinical applications.
In terms of scientific importance, AKAP9 knockouts contribute to our understanding of the intricate networks that govern cellular behavior. Applications span across fundamental research, including drug discovery, tumor biology studies, and the development of novel treatment modalities. Compared to alternatives, such as overexpression systems or partial knockdowns, these knockout cell lines provide a clearer picture of gene function and the resulting phenotypic changes, enhancing the quality of experimental data.
The unique advantages of our AKAP9 Gene Knockout Cell Lines lie in their validated performance and reproducibility, which are crucial for rigorous experimental designs. By eliminating confounding variables associated with incomplete knockdowns, our product empowers researchers to produce more conclusive results.
For scientists, researchers, and clinicians, the value of these knockout cell lines is evident; they offer a reliable resource for advancing our understanding of AKAP9-related pathways and their implications in various diseases.
Our company prides itself on delivering high-quality biological products backed by extensive expertise in genetic engineering and cell biology. We are committed to supporting the scientific community with cutting-edge tools that drive innovation and discovery in research and clinical settings.
Please note that all services are for research use only. Not intended for any clinical use.
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