Gene: ACAD9
Official Full Name: acyl-CoA dehydrogenase family member 9provided by HGNC
Gene Summary: This gene encodes a member of the acyl-CoA dehydrogenase family. Members of this family of proteins localize to the mitochondria and catalyze the rate-limiting step in the beta-oxidation of fatty acyl-CoA. The encoded protein is specifically active toward palmitoyl-CoA and long-chain unsaturated substrates. Mutations in this gene cause acyl-CoA dehydrogenase family member type 9 deficiency. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27256 | ACAD9 Knockout cell line (HeLa) | Human | ACAD9 | 1:3~1:6 | Negative | Online Inquiry |
KO27257 | ACAD9 Knockout cell line (HCT 116) | Human | ACAD9 | 1:2~1:4 | Negative | Online Inquiry |
KO27258 | ACAD9 Knockout cell line (HEK293) | Human | ACAD9 | 1:3~1:6 | Negative | Online Inquiry |
KO27259 | ACAD9 Knockout cell line (A549) | Human | ACAD9 | 1:3~1:4 | Negative | Online Inquiry |
ACAD9 Gene Knockout Cell Lines are genetically modified cell lines designed to elucidate the functions of the ACAD9 gene, which encodes a key enzyme involved in mitochondrial fatty acid metabolism. These knockout lines are created using advanced CRISPR/Cas9 technology to specifically disrupt the ACAD9 gene, allowing researchers to investigate the biological consequences of gene loss in various cellular contexts. The primary function of the ACAD9 protein is to facilitate the transport and oxidation of long-chain fatty acids, crucial for energy production and metabolic homeostasis within mitochondria.
The scientific importance of ACAD9 Gene Knockout Cell Lines lies in their application in understanding metabolic disorders, mitochondrial dysfunction, and the implications of altered energy metabolism in diseases such as obesity, diabetes, and certain neurodegenerative disorders. These cell lines serve as invaluable tools in research settings, enabling researchers to study the effects of ACAD9 deficiency on cellular metabolism, apoptosis, and overall cell viability, thus offering insights into potential therapeutic targets.
What sets our ACAD9 Gene Knockout Cell Lines apart from alternatives is the rigorous quality control and characterization performed during development, ensuring stable gene disruption and reproducible results across experiments. Additionally, our cell lines have been extensively validated in multiple genetic backgrounds, further enhancing their applicability in diverse research scenarios.
Researchers and clinicians would find significant value in these cell lines as they enable the exploration of complex metabolic pathways that are often difficult to analyze in vivo. By providing a clear model to study the repercussions of ACAD9 knockout, these cell lines facilitate the identification of novel therapeutic strategies and contribute to the advancement of precision medicine.
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Please note that all services are for research use only. Not intended for any clinical use.
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