VHL Knockout cell line(HCT 116)

Catalog Number: KOA417610

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Specifications

Product Information
Product Name	VHL Knockout cell line(HCT 116)
specification	1*10^6
Storage and transportation	Shipped on dry ice; Store in liquid nitrogen
Cell morphology	Epithelial-like, adherent
Passage ratio	1:2~1:4
species	Human
Gene	VHL
Gene ID	7428
Build method	Electroporation/Lentivirus
Mycoplasma testing	negative
Cultivation system	90%McCOY's 5A+10% FBS
Parental Cell Line	HCT 116
Quality Control	Genotype: VHL Knockout cell line(HCT 116)>95% viability before freezing. All cells were tested and found to be free of bacterial, viruses,mycoplasma and other toxins.

Gene Information
Gene Official Full Name	von Hippel-Lindau tumor suppressorprovided by HGNC
Also known as	RCA1; VHL1; pVHL; HRCA1
Gene Description	This gene encodes a component of a ubiquitination complex. The encoded protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. In addition to oxygen-related gene expression, this protein plays a role in many other cellular processes including cilia formation, cytokine signaling, regulation of senescence, and formation of the extracellular matrix. Variants of this gene are associated with von Hippel-Lindau syndrome, pheochromocytoma, erythrocytosis, renal cell carcinoma, and cerebellar hemangioblastoma. [provided by RefSeq, Jun 2022]
Expression	Ubiquitous expression in lymph node (RPKM 12.2), spleen (RPKM 10.0) and 25 other tissues See more

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