Bisabolol (Sesquiterpene) Strain Engineering Service

Bisabolol is a valuable sesquiterpene alcohol widely used in cosmetics and medicine for its anti-inflammatory and skin-soothing properties. Traditional production methods, such as plant extraction, suffer from long cycles and low yield, while chemical synthesis generates significant pollution, driving the need for sustainable bioproduction alternatives.

CD Biosynsis specializes in engineering microbial hosts for high-efficiency terpene synthesis. We focus on modifying the model Streptomyces chassis strain and overexpressing key enzymes in the mevalonate (MEV) or MEP pathways. Our goal is to achieve high-titer, high-purity Bisabolol production, overcoming the issues of long cycles and pollution. We provide clients with advanced, environmentally friendly strain solutions to support the green production revolution in the specialty chemical and cosmetics industries.

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Pain Points Solutions Advantages Process FAQ

Pain Points

In Bisabolol production, limitations in traditional methods present critical hurdles for industrial supply:

Long Plant Extraction Cycle: Sourcing Bisabolol from natural sources (like chamomile) is hindered by low content in the raw material and a long cultivation and extraction cycle , leading to supply instability and high costs.
Significant Chemical Pollution: Chemical synthesis often relies on petroleum-based precursors and harsh reaction conditions, resulting in large chemical pollution and difficulty in achieving chiral purity required for high-end applications.
Insufficient Terpene Precursor Supply: Microbial hosts naturally prioritize carbon flux toward essential primary metabolism. The supply of the key terpene precursor Farnesyl Diphosphate FPP ) is severely limited, restricting the final Bisabolol yield.
Low Activity of Target Synthase: The Bisabolol Synthase enzyme often exhibits suboptimal catalytic efficiency or promiscuity in heterologous hosts, leading to the formation of undesired terpene byproducts.

A sustainable solution must involve redesigning the metabolic pathways of a robust microbial host to efficiently channel carbon flux toward Bisabolol synthesis.

Solutions

CD Biosynsis employs targeted metabolic engineering strategies to establish a high-performance microbial platform for Bisabolol synthesis, ensuring high titer and purity:

Modification of Model Streptomyces Chassis

We utilize the robust metabolism of Streptomyces to overcome toxicity and yield limitations. The host is engineered for enhanced stress tolerance and efficient utilization of low-cost carbon sources.

Overexpression of Terpene Pathway Key Enzymes

Key genes HMG-CoA Reductase, FPP Synthase) in the MEV pathway are overexpressed and balanced to drastically increase the intracellular supply of the Bisabolol precursor, FPP .

Bisabolol Synthase Optimization

The target Bisabolol Synthase gene is codon-optimized and functionally enhanced (e.g., through promoter engineering) to maximize its activity, ensuring efficient conversion of FPP to the final product.

Product Export and Toxicity Management

Efflux pumps are engineered or overexpressed to enhance the secretion and export of Bisabolol from the cell, reducing product toxicity and minimizing degradation, thereby boosting overall recovery.

This strategy focuses on maximizing the synthetic pathway flux within the microbial host for sustainable, high-volume production.

Advantages

Choosing CD Biosynsis's Bisabolol strain engineering service offers the following core value:

Terpene Pathway Specialization

We possess deep expertise in engineering the MEV and MEP pathways, the core routes for terpene synthesis, enabling precise and predictable flux control.

Sustainable and Low-Pollution Output

The microbial fermentation process offers an eco-friendly alternative to chemical synthesis, drastically reducing pollution and waste byproducts.

Guaranteed Purity and Chiral Control

Enzyme-driven biosynthesis naturally produces the desired chiral isomer ($\alpha$-Bisabolol) with high purity, which is challenging and costly to achieve via chemical routes.

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CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.

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Bisabolol (Sesquiterpene) Strain Engineering Service

Pain Points

Solutions

Advantages

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