Epoxy Resin Precursors Engineering Service

Epoxy Resin Precursors are foundational chemical building blocks for high-performance Coatings/Composites e.g. aerospace materials, protective paints, wind turbine blades. Production challenges stem from the traditional route: they are Traditionally petrochemical-derived Bisphenol A/Epichlorohydrin and the starting materials and products often carry high toxicity and environmental risk. This drives the need for sustainable, bio-based alternatives.

CD Biosynsis offers a two-pronged metabolic engineering strategy to produce bio-based resin precursors: Metabolic Engineering: Biosynthesis of Epichlorohydrin from Glycerol a biodiesel by-product using engineered microbes. Glycerol is a cheap, abundant feedstock. We also focus on developing sustainable Bisphenol A substitutes via Develop bio-based Bisphenol alternatives e.g., from Tyrosine via Phenylpropanoid pathway engineering . This strategy replaces the two primary petrochemical components with non-toxic, bio-based alternatives, significantly reducing environmental and health hazards.

Pain Points

The transition to sustainable epoxy resin precursors faces these key hurdles:

• Petrochemical Dependence: Reliance on Bisphenol A BPA and Epichlorohydrin ECH ties the resin market to the petrochemical industry and price volatility.
• High Toxicity and Hazard: Both BPA and ECH are known for their high toxicity and environmental persistence, with BPA being a known endocrine disruptor.
• Pathway Complexity: The biosynthesis of both ECH from glycerol and the aromatic Bisphenol A alternatives from sugar/tyrosine requires complex, multi-step metabolic pathway engineering , often involving novel enzymes.
• Feedstock Purity and Cost: Ensuring the final bio-precursor products meet the high purity standards required for polymer applications, especially when starting from crude waste streams like glycerol.

A successful solution requires replacing both petrochemical precursors with high-purity, bio-derived alternatives.

Solutions

CD Biosynsis utilizes comprehensive metabolic engineering to produce bio-based epoxy precursors:

Biosynthesis of Epichlorohydrin

           

We engineer microbes to efficiently convert crude glycerol through intermediates like 3-chloropropanediol into the Epichlorohydrin ECH precursor in a sustainable process.

Bio-Bisphenol Alternatives

We use phenylpropanoid pathway engineering to synthesize Bisphenol alternatives e.g. Tyrosinol-based compounds from cheap carbon sources or Tyrosine, eliminating the need for toxic BPA.

Multi-Enzyme Cascade Optimization

The biosynthesis of these precursors involves multi-step enzyme cascades . We optimize enzyme expression and balance the flux to ensure high yield and minimal byproduct formation for polymer-grade purity.

Halogenation Pathway Control

For ECH production, we manage the in-vivo halogenation reaction to control product toxicity and maximize the efficiency of the final cyclization to Epichlorohydrin.

This systematic approach replaces the toxic petrochemical value chain with a safe, sustainable bioproduction platform.

Advantages

Our Epoxy Resin Precursor engineering service is dedicated to pursuing the following production goals:

Sustainable Feedstock Utilization Icon

Utilization of crude glycerol and sugar-derived intermediates replaces fossil fuel dependence.

Eliminate High Toxicity Precursors Icon

Replacement of BPA and petrochemical ECH removes major health and environmental hazards.

High Polymer-Grade Purity Icon

Precision metabolic engineering ensures the final bio-monomer meets the strict purity requirements for polymerization.

Improved Pathway Efficiency Icon

Enzyme and flux optimization leads to high conversion yields of feedstock to bio-precursor product.

Safer Bioprocess Icon

Microbial production operates under mild conditions, reducing the risk associated with hazardous chemical synthesis.

We deliver an innovative and safe platform for next-generation bio-based epoxy resins.

Process

Our Epoxy Resin Precursor engineering service follows a rigorous, multi-stage research workflow:

• Epichlorohydrin Pathway Engineering: Introduce the necessary genes for glycerol conversion including halohydrin dehalogenase to enable biosynthesis of Epichlorohydrin from glycerol.
• Aromatic Precursor Pathway Design: Engineer the Phenylpropanoid pathway to synthesize the desired Bisphenol A replacement molecule e.g. from Tyrosine or other amino acids.
• Toxicity and Flux Optimization: Optimize gene expression levels and enzyme balance to overcome intermediate toxicity and maximize carbon flux through the multi-step pathways.
• Fermentation Process Development: Develop high-cell-density fermentation protocols using low-cost feedstocks like crude glycerol to achieve maximal product titer for both ECH and the aromatic alternative.
• Product Purity and Yield Analysis: Quantify the final titer and high-purity yield of the desired bio-precursor products and validate them for downstream polymerization compatibility.

Technical communication is maintained throughout the process, focusing on timely feedback regarding yield and product quality attributes.

Explore the potential for a sustainable, low-toxicity epoxy resin value chain. CD Biosynsis provides customized strain and process engineering solutions:

• Detailed Bio-Epichlorohydrin and Aromatic Precursor Titer Reports g/L from optimized fermentation runs.
• Consultation on downstream purification to polymer-grade purity for both monomers.
• Experimental reports include complete raw data on strain stability, enzyme activities, and byproduct profile analysis .