CYP1A1 Knockout cell line (U-2932)

Catalog Number: KOA47181

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Specifications

Product Information
Product Name	CYP1A1 Knockout cell line (U-2932)
specification	1*10^6
Storage and transportation	Shipped on dry ice; Store in liquid nitrogen
Cell morphology	Human Lymphocyte-like, suspension
Passage ratio	1：2-1：4
species	Human
Gene	CYP1A1
Gene ID	1543
Build method	Electroporation/Lentivirus
Mycoplasma testing	negative
Cultivation system	90%RPMI-1640+10%FBS
Parental Cell Line	U-2932
Quality Control	Genotype: CYP1A1 Knockout cell line (U-2932)>95% viability before freezing. All cells were tested and found to be free of bacterial, viruses,mycoplasma and other toxins.

Gene Information
Gene Official Full Name	cytochrome P450 family 1 subfamily A member 1provided by HGNC
Also known as	AHH; AHRR; CP11; CYP1; CYPIA1; P1-450; P450-C; P450DX
Gene Description	This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
Expression	Biased expression in urinary bladder (RPKM 40.8), liver (RPKM 18.0) and 1 other tissue See more

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