Gene: USH1G
Official Full Name: USH1 protein network component sansprovided by HGNC
Gene Summary: This gene encodes a protein that contains three ankyrin domains, a class I PDZ-binding motif and a sterile alpha motif. The encoded protein interacts with harmonin, which is associated with Usher syndrome type 1C. This protein plays a role in the development and maintenance of the auditory and visual systems and functions in the cohesion of hair bundles formed by inner ear sensory cells. Mutations in this gene are associated with Usher syndrome type 1G (USH1G). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28008 | USH1G Knockout cell line (HCT 116) | Human | USH1G | 1:2~1:4 | Negative | Online Inquiry |
USH1G Gene Knockout Cell Lines represent a groundbreaking tool in genetic research and therapeutic development, specifically targeting the USH1G gene associated with Usher syndrome—a condition characterized by hearing loss and progressive vision loss. These cell lines have been meticulously engineered through CRISPR-Cas9 technology, which allows for precise genomic editing, creating a knockout model that provides insights into the gene's function and its implications in the pathology of Usher syndrome.
The primary function of these cell lines is to facilitate the exploration of cellular mechanisms impacted by the absence of the USH1G gene. Researchers can utilize these models to investigate cellular responses, signal transduction pathways, and any compensatory mechanisms at play, thereby illuminating the molecular underpinnings of hearing and vision-related disorders. The ability to analyze gene interactions and the effects on cellular behavior in vitro enhances our understanding of the genotype-phenotype relationship inherent to genetic disorders.
In both research and clinical settings, USH1G Gene Knockout Cell Lines are invaluable for biologists and geneticists investigating potential therapeutic targets or devising gene therapies. These models provide a platform for screening small molecules or candidate drugs that may alleviate symptoms of Usher syndrome, thereby expediting the transition from bench to bedside. Additionally, they offer a more refined alternative compared to traditional animal models, enabling more accurate and ethical experimentation.
What sets our USH1G Gene Knockout Cell Lines apart is their exceptional reliability and reproducibility, ensuring that researchers can obtain consistent results throughout their studies. Coupled with our commitment to quality and customer support, these cell lines are specifically designed to integrate seamlessly into existing workflows and are readily available for immediate use.
Our company takes pride in its expertise in genetic engineering and cell line development, consistently providing innovative solutions that drive scientific discovery. By utilizing our USH1G Gene Knockout Cell Lines, researchers and clinicians alike can push the boundaries of current knowledge and contribute to the advancement of therapies for genetic conditions, making a significant impact in the field of regenerative medicine.
Please note that all services are for research use only. Not intended for any clinical use.
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