Gene: TRIB3
Official Full Name: tribbles pseudokinase 3provided by HGNC
Gene Summary: The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00390 | TRIB3 Knockout cell line(U-87MG) | Human | TRIB3 | 1:3~1:4 | Negative | Online Inquiry |
KO02746 | TRIB3 Knockout cell line (HeLa) | Human | TRIB3 | 1:3~1:6 | Negative | Online Inquiry |
KO02747 | TRIB3 Knockout cell line (HCT 116) | Human | TRIB3 | 1:2~1:4 | Negative | Online Inquiry |
KO02748 | TRIB3 Knockout cell line (HEK293) | Human | TRIB3 | 1:3~1:6 | Negative | Online Inquiry |
KO02749 | TRIB3 Knockout cell line (A549) | Human | TRIB3 | 1:3~1:4 | Negative | Online Inquiry |
TRIB3 Gene Knockout Cell Lines are engineered cellular models designed to investigate the functional role of the TRIB3 gene, which encodes a member of the tribbles family of proteins implicated in various cellular processes, including metabolism, apoptosis, and inflammatory responses. These cell lines are generated through advanced CRISPR-Cas9 gene-editing technology, ensuring precise knockout of the TRIB3 gene, thereby enabling researchers to study the gene's absence and its effects on cellular behavior and signaling pathways.
The primary function of TRIB3 is to modulate cellular stress responses, particularly in the context of insulin signaling and endoplasmic reticulum stress. By knocking out TRIB3, these cell lines provide a powerful tool for elucidating TRIB3's role in diseases such as diabetes, cancer, and cardiovascular disorders. Researchers can explore how the loss of TRIB3 influences metabolic pathways, cellular proliferation, and resistance to apoptosis, offering insights that could lead to novel therapeutic strategies.
In the realm of scientific research, TRIB3 Gene Knockout Cell Lines hold significant importance as they facilitate the dissection of TRIB3's specific contributions to pathophysiological processes. The availability of such cell lines accelerates the pace of research, supporting drug discovery efforts and the development of personalized medicine approaches. Compared to traditional methods, these knockout models provide a more accurate reflection of human disease mechanisms, allowing for more relevant preclinical studies.
One of the key advantages of using our TRIB3 Gene Knockout Cell Lines is the high specificity and efficiency of the CRISPR-Cas9 method employed during their development, which significantly reduces off-target effects often seen with prior gene-editing technologies. Furthermore, these cell lines come with consistent characterization and validation, ensuring reliable results across experiments, thus enhancing reproducibility—a critical factor in scientific research.
For researchers and clinicians alike, the TRIB3 Gene Knockout Cell Lines represent a vital resource, enabling deeper investigation into the biological roles of TRIB3 and promoting advancements in therapeutic approaches. Our company specializes in providing high-quality biological products, leveraging cutting-edge technologies to support your research endeavors effectively.
Please note that all services are for research use only. Not intended for any clinical use.
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