Gene: TMEM165
Official Full Name: transmembrane protein 165provided by HGNC
Gene Summary: This gene encodes a predicted transmembrane protein with a perinuclear Golgi-like distribution in fibroblasts. Mutations in this gene are associated with the autosomal recessive disorder congenital disorder of glycosylation, type IIk. Knockdown of this gene's expression causes decreased sialylation in HEK cells and suggests this gene plays a role in terminal Golgi glycosylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00335 | TMEM165 Knockout cell line (HeLa) | Human | TMEM165 | 1:3~1:6 | Negative | Online Inquiry |
KO20703 | TMEM165 Knockout cell line (HCT 116) | Human | TMEM165 | 1:2~1:4 | Negative | Online Inquiry |
KO20704 | TMEM165 Knockout cell line (HEK293) | Human | TMEM165 | 1:3~1:6 | Negative | Online Inquiry |
KO20705 | TMEM165 Knockout cell line (A549) | Human | TMEM165 | 1:3~1:4 | Negative | Online Inquiry |
TMEM165 Gene Knockout Cell Lines are specialized cell models that have undergone targeted genetic modification to eliminate the expression of the TMEM165 gene, which encodes a lysosomal protein implicated in various cellular processes, including calcium homeostasis and glycosylation pathways. This innovative tool enables researchers to investigate the precise role of the TMEM165 gene in health and disease, particularly its contributions to lysosomal storage disorders and other metabolic syndromes.
The key function of these cell lines lies in their capacity to study the consequences of TMEM165 knockout on cellular physiology, molecular signaling, and pathophysiological mechanisms. By observing the aberrations in cellular function under conditions devoid of TMEM165, researchers can uncover critical insights into the gene's involvement in calcium signaling, ion transport, and the maintenance of cellular homeostasis. This knowledge is vital in understanding the molecular basis of diseases associated with dysfunctional lysosomal activity.
The scientific importance of TMEM165 Gene Knockout Cell Lines extends into both research and clinical settings. In research, these cell lines serve as a model system for investigating lysosomal function and its links to diseases such as Musculocontractural Ehlers-Danlos syndrome and other inherited disorders. Clinically, insights gained through studies using these models can pave the way for the development of targeted therapies and novel approaches to treat lysosomal dysfunctions.
What sets our TMEM165 Gene Knockout Cell Lines apart from alternative products is their high specificity, validated performance, and ease of use in various experimental settings. Researchers can benefit from the reliability of these cell lines, which ensure reproducibility and accuracy in experimental outcomes, aiding in robust data generation. Furthermore, these cell lines are rigorously characterized at the genomic and phenotypic levels, which provides an added layer of confidence for end-users.
In conclusion, TMEM165 Gene Knockout Cell Lines represent a valuable resource for scientists and healthcare professionals exploring the intricate biology of lysosomal diseases. Our company is committed to providing high-quality biological products, backed by rigorous research and expertise, to empower the scientific community in their quest for innovative solutions to complex biological challenges.
Please note that all services are for research use only. Not intended for any clinical use.
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