Gene: SPDEF
Official Full Name: SAM pointed domain containing ETS transcription factorprovided by HGNC
Gene Summary: The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03284 | SPDEF Knockout cell line (A549) | Human | SPDEF | 1:3~1:4 | Negative | Online Inquiry |
SPDEF Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to elucidate the role of the Suppressor of Cancer Gene 3 (SPDEF) in various biological processes. SPDEF is known to play a crucial role in cell differentiation, proliferation, and tumor progression. Utilizing advanced CRISPR-Cas9 technology, our SPDEF knockout cell lines enable researchers to achieve precise gene editing, creating an effective platform to investigate SPDEF's functions and signaling pathways.
These knockout cell lines are instrumental in studying the molecular mechanisms underlying various diseases, especially related to cancer, given SPDEF’s involvement in epithelial-to-mesenchymal transition (EMT) and metastasis. By disrupting SPDEF expression, researchers can explore how its absence alters cellular behaviors and contributes to disease pathology, providing valuable insights that may influence therapeutic strategies. Furthermore, these cell lines facilitate the screening of potential drug candidates by allowing the investigation of therapeutic responses in SPDEF-deficient backgrounds, making them an essential tool in both basic and translational research.
What sets our SPDEF Gene Knockout Cell Lines apart from alternatives is the high efficiency and specificity of our CRISPR-based approach, which minimizes off-target effects and maximizes gene editing precision. Additionally, our cell lines come with detailed characterization data, ensuring that researchers can readily interpret their experimental results with confidence.
For scientists and clinicians seeking to pioneer advancements in cancer research and therapeutic interventions, our SPDEF Gene Knockout Cell Lines represent a valuable asset. They not only enhance the understanding of SPDEF-related pathways but also open doors for innovative research applications that could lead to breakthroughs in drug development. With years of experience in genetic engineering and cellular biology, our company is dedicated to providing high-quality, reliable biological products that empower the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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