Gene: PRSS3
Official Full Name: serine protease 3provided by HGNC
Gene Summary: This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01512 | PRSS3 Knockout cell line (HCT 116) | Human | PRSS3 | 1:2~1:4 | Negative | Online Inquiry |
KO01513 | PRSS3 Knockout cell line (A549) | Human | PRSS3 | 1:3~1:4 | Negative | Online Inquiry |
PRSS3 Gene Knockout Cell Lines are engineered cellular models in which the PRSS3 gene, encoding for the serine protease enzyme, has been specifically disrupted. This targeted knockout allows researchers to study the functional role of PRSS3 in disease progression, cellular signaling, and enzymatic pathways in a controlled environment. These cell lines serve as an essential tool in gaining insight into the molecular mechanisms underpinning various pathologies, particularly in pancreatic function and cancer biology.
The functionality of PRSS3 Gene Knockout Cell Lines is rooted in the complete absence of PRSS3 protein expression, enabling the dissection of PRSS3's specific contributions to proteolytic activity, cell proliferation, and apoptosis. By leveraging the unique genetic modification, scientists can elucidate signaling cascades that are impacted by the absence of PRSS3, ultimately leading to a deeper understanding of its role in health and disease. This makes the cell lines a pivotal resource for both fundamental research and therapeutic explorations.
The scientific significance of these cell lines is immense, particularly as they enable translational research aimed at developing novel therapies for pancreatic diseases and cancers. Unlike traditional cell lines that may express varying levels of functional PRSS3, these knockout models offer uniformity and clarity in experimental outcomes, bolstering the reliability of research findings. Additionally, they facilitate efforts in drug discovery and testing by allowing for the identification of potential inhibitors or modulators of PRSS3 activity.
One of the standout advantages of the PRSS3 Gene Knockout Cell Lines is their specificity and reproducibility, ensuring that researchers can achieve consistent and reliable results. This specificity can lead to faster bench-to-bedside translations regarding understanding and treating conditions linked to PRSS3 dysregulation, such as pancreatitis and certain types of cancer.
Researchers and clinicians value these cell lines not only for their utility in innovation but also for their ability to streamline experimental workflows, enabling impactful discoveries while minimizing experimental variability. As a product offering from a company that specializes in advanced biological research tools, the PRSS3 Gene Knockout Cell Lines exemplify our commitment to providing uniquely tailored solutions that empower the scientific community in their pursuit of knowledge and therapeutic breakthroughs.
Please note that all services are for research use only. Not intended for any clinical use.
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