Gene: PPP3CC
Official Full Name: protein phosphatase 3 catalytic subunit gammaprovided by HGNC
Gene Summary: Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10545 | PPP3CC Knockout cell line (HeLa) | Human | PPP3CC | 1:3~1:6 | Negative | Online Inquiry |
KO10546 | PPP3CC Knockout cell line (HCT 116) | Human | PPP3CC | 1:2~1:4 | Negative | Online Inquiry |
KO10547 | PPP3CC Knockout cell line (HEK293) | Human | PPP3CC | 1:3~1:6 | Negative | Online Inquiry |
KO10548 | PPP3CC Knockout cell line (A549) | Human | PPP3CC | 1:3~1:4 | Negative | Online Inquiry |
PPP3CC Gene Knockout Cell Lines are a specialized biological tool designed for the study of the PPP3CC gene, which encodes the catalytic subunit of protein phosphatase 3, a key regulator of various cellular processes, including calcium signaling and cell cycle regulation. These cell lines have been engineered to possess a complete knockout of the PPP3CC gene, allowing for a more refined investigation of its biological functions and related pathways without the interference of the target protein.
The primary function of these knockout cell lines is to facilitate the elucidation of PPP3CC's role in cellular signaling and its involvement in diseases. Researchers can utilize these cell lines to perform functional assays that assess cell proliferation, apoptosis, and other critical cellular responses, all of which depend on the phosphatase activity of PPP3CC. The absence of this gene enables scientists to identify compensatory mechanisms or alternative pathways activated in response to its loss, broadening our understanding of various physiological and pathological conditions.
In the realm of scientific importance, these cell lines are invaluable in both research and clinical settings. They provide a stable platform for drug discovery, allowing for the screening of small molecules that may target downstream effects of altered calcium signaling or associated diseases, such as cardiac disorders or neurodegenerative diseases. Additionally, they can aid in the validation of therapeutic targets in clinical trials, offering insights into efficacy and safety profiles for new treatments.
Compared to conventional cell lines with intact gene expression, PPP3CC Gene Knockout Cell Lines present a unique advantage by eliminating background noise from other phosphatase activities, thereby ensuring specificity in experimental results. This precision increases the reliability of data, making them more robust for publication and subsequent application in clinical trials.
For researchers and clinicians focused on cellular signaling and disease mechanisms, PPP3CC Gene Knockout Cell Lines are indispensable. They empower scientists to delve deeper into the intricate workings of cellular processes affected by PPP3CC, ultimately facilitating breakthrough discoveries and therapeutic advances.
Our company specializes in providing high-quality biological tools that enhance research capabilities. With extensive expertise in genetic engineering and a commitment to innovation, we are dedicated to supporting the scientific community with products that drive impactful research and clinical solutions.
Please note that all services are for research use only. Not intended for any clinical use.
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