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ARAP1 Knockout Cell Lines

Gene: ARAP1

Official Full Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1provided by HGNC

Gene Summary: The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30473 ARAP1 Knockout cell line (HeLa) Human ARAP1 1:3~1:6 Negative Online Inquiry
KO30474 ARAP1 Knockout cell line (HCT 116) Human ARAP1 1:2~1:4 Negative Online Inquiry
KO30475 ARAP1 Knockout cell line (HEK293) Human ARAP1 1:3~1:6 Negative Online Inquiry
KO30476 ARAP1 Knockout cell line (A549) Human ARAP1 1:3~1:4 Negative Online Inquiry

Background

ARAP1 Gene Knockout Cell Lines represent a significant advancement in the study of molecular biology and genetics. These cell lines are specifically engineered to lack the ARAP1 gene, enabling researchers to investigate the gene's function and its implications in various biological processes and disease states. The ARAP1 protein is implicated in cellular signaling pathways, particularly those related to lipid metabolism and cytoskeletal organization, making these knockout lines invaluable for dissecting its role in health and disease.

The mechanism of ARAP1 gene knockout involves targeted CRISPR/Cas9 technology, which edits the genome of the cell lines to induce precise deletions in the ARAP1 locus. This results in the complete absence of the ARAP1 protein, providing a robust platform for elucidating the cellular responses and compensatory mechanisms activated in its absence. Researchers can leverage these knockout cell lines to perform functional assays, study gene interactions, and explore disease phenotypes associated with ARAP1 deficiencies, particularly in areas like cancer biology and metabolic syndrome.

The scientific importance of ARAP1 Gene Knockout Cell Lines is underscored by their potential applications across a spectrum of research fields. They serve as a critical tool in drug discovery, enabling scientists to assess the efficacy of therapeutic agents in a controlled environment devoid of the ARAP1 protein. Furthermore, these lines can aid in the development of novel gene therapies, enhancing our understanding of genetic disorders linked to ARAP1.

One of the unique selling points of our ARAP1 Gene Knockout Cell Lines is the unparalleled specificity and reliability that come from our meticulously validated CRISPR editing process. Compared to alternative products on the market, our offering includes comprehensive characterization data, ensuring that researchers can confidently use these models in their investigations without the concerns of off-target effects.

For researchers and clinicians dedicated to pioneering advancements in genetic research, the value of ARAP1 Gene Knockout Cell Lines lies in their ability to facilitate groundbreaking discoveries and contribute to our collective knowledge in genetics and cellular biology. By choosing our product, users benefit from our company’s extensive expertise in genetic manipulation and commitment to providing high-quality biological research tools.

Please note that all services are for research use only. Not intended for any clinical use.

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