TNFSF9 Knockout cell line (MRC-5)

Catalog Number: KOA89733

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Specifications

Product Information
Product Name	TNFSF9 Knockout cell line (MRC-5)
specification	1*10^6
Storage and transportation	Shipped on dry ice; Store in liquid nitrogen
Cell morphology	Fibroblast-like, adherent
Passage ratio	1：2-1：3
species	Human
Gene	TNFSF9
Gene ID	8744
Build method	Electroporation/Lentivirus
Mycoplasma testing	negative
Cultivation system	90%DMEM+10%FBS
Parental Cell Line	MRC-5
Quality Control	Genotype: TNFSF9 Knockout cell line (MRC-5)>95% viability before freezing. All cells were tested and found to be free of bacterial, viruses,mycoplasma and other toxins.

Gene Information
Gene Official Full Name	TNF superfamily member 9provided by HGNC
Also known as	CD137L; TNLG5A; 4-1BB-L
Gene Description	The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]
Expression	Broad expression in colon (RPKM 1.1), bone marrow (RPKM 1.0) and 18 other tissues See more

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