Gene: ZNF391
Official Full Name: zinc finger protein 391provided by HGNC
Gene Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO12271 | ZNF391 Knockout cell line (HCT 116) | Human | ZNF391 | 1:2~1:4 | Negative | Online Inquiry |
KO12272 | ZNF391 Knockout cell line (HEK293) | Human | ZNF391 | 1:3~1:6 | Negative | Online Inquiry |
ZNF391 Gene Knockout Cell Lines are invaluable tools in cellular and molecular biology research, specifically designed to facilitate the study of the ZNF391 gene, a crucial regulator of various biological processes such as transcriptional control and cellular differentiation. These cell lines are genetically engineered to exhibit a complete knockout of the ZNF391 gene, enabling researchers to investigate the gene's functions and its role in disease mechanisms without the influence of its protein product.
The primary mechanism behind ZNF391 Gene Knockout Cell Lines involves CRISPR-Cas9 technology or similar genomic editing techniques, which introduce specific double-strand breaks within the ZNF391 coding sequence. The resultant loss-of-function mutations inhibit the production of the ZNF391 protein, allowing for the observation of phenotypic changes that arise from its absence. By utilizing these cell lines, researchers can dissect downstream signaling pathways and identify compensatory mechanisms that may occur in the absence of ZNF391, thus elucidating its functional significance.
The scientific importance of these cell lines extends across various applications, including basic research in gene function, drug discovery, and the development of potential therapeutic interventions. They are particularly valuable in the study of cancer biology, as anomalies in zinc-finger transcription factors like ZNF391 have been implicated in tumorigenesis and metastasis.
What sets ZNF391 Gene Knockout Cell Lines apart from alternatives is their high specificity and reliability. Unlike other models that may exhibit off-target effects or retain partial gene function, these knockout lines provide a clean genetic background, thereby minimizing confounding variables in experimental results. Additionally, their easy integration into existing laboratory workflows ensures that researchers can rapidly advance their studies without extensive optimization.
For researchers, clinicians, and pharmacologists, ZNF391 Gene Knockout Cell Lines are essential for advancing our understanding of gene function in health and disease. These cell lines not only accelerate the pace of discovery but also provide a robust framework for translating findings into clinical applications.
Our company specializes in providing high-quality biological research tools, and our expertise in gene editing and cell line development ensures that our products meet the highest scientific standards, empowering you to achieve your research goals effectively.
Please note that all services are for research use only. Not intended for any clinical use.
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