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ZNF136 Knockout Cell Lines

Gene: ZNF136

Official Full Name: zinc finger protein 136provided by HGNC

Gene Summary: This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) A-box domain at its N-terminus, followed by fourteen contiguous C2H2 zinc finger domains and a degenerate zinc finger. The KRAB A-box showed weak transcriptional repressor activity in a reporter gene assay. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34605 ZNF136 Knockout cell line (HeLa) Human ZNF136 1:3~1:6 Negative Online Inquiry
KO34606 ZNF136 Knockout cell line (HCT 116) Human ZNF136 1:2~1:4 Negative Online Inquiry
KO34607 ZNF136 Knockout cell line (HEK293) Human ZNF136 1:3~1:6 Negative Online Inquiry
KO34608 ZNF136 Knockout cell line (A549) Human ZNF136 1:3~1:4 Negative Online Inquiry

Background

ZNF136 Gene Knockout Cell Lines are specialized cellular models designed to facilitate the comprehensive study of the ZNF136 gene's function within various biological processes. Utilizing advanced CRISPR-Cas9 gene editing technology, these cell lines have been meticulously engineered to disrupt the ZNF136 gene, allowing researchers to investigate the resultant phenotypic alterations and elucidate the gene's roles in cellular mechanisms, such as gene regulation, cell proliferation, and apoptosis.

The primary function of ZNF136 Gene Knockout Cell Lines is to serve as an invaluable tool for dissecting the impact of ZNF136 on critical cellular pathways. By creating a loss-of-function model, researchers can observe changes in gene expression profiles, analyze downstream signaling cascades, and assess alterations in cellular morphology and behavior. This unique cell line is pivotal for studies exploring the implications of ZNF136 in diseases, particularly in cancer biology, where gene dysregulation often leads to tumorigenesis.

The scientific significance of ZNF136 Gene Knockout Cell Lines extends into both research and clinical applications. In academic laboratories, these cell lines enable the exploration of fundamental biological questions, while in translational medicine, they promote the identification of potential therapeutic targets for diseases associated with ZNF136 dysregulation.

Compared to existing alternatives, such as wild-type cell lines or RNA interference systems, ZNF136 Gene Knockout Cell Lines present the distinct advantage of complete gene knockout, thereby providing clearer insights into gene function without the confounding effects of residual gene expression. This specificity equips researchers with a precise experimental platform that enhances data accuracy and reproducibility.

Researchers and clinicians can leverage the ZNF136 Gene Knockout Cell Lines to deepen their understanding of genetic regulation and its role in health and disease, ultimately guiding innovative therapeutic developments. Our commitment to providing high-quality biological products, coupled with a focus on cutting-edge methodologies, positions our company as a trusted leader in the field of gene editing tools. With our expertise, we empower scientists in their quest to unravel the complexities of gene function and develop strategies for clinical interventions.

Please note that all services are for research use only. Not intended for any clinical use.

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