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ZFX Knockout Cell Lines

Gene: ZFX

Official Full Name: zinc finger protein X-linkedprovided by HGNC

Gene Summary: This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03145 ZFX Knockout cell line (HeLa) Human ZFX 1:3~1:6 Negative Online Inquiry
KO03146 ZFX Knockout cell line (HCT 116) Human ZFX 1:2~1:4 Negative Online Inquiry
KO03147 ZFX Knockout cell line (HEK293) Human ZFX 1:3~1:6 Negative Online Inquiry
KO03148 ZFX Knockout cell line (A549) Human ZFX 1:3~1:4 Negative Online Inquiry

Background

ZFX Gene Knockout Cell Lines represent a cutting-edge tool in molecular biology designed to facilitate the study of gene function and regulation. These cell lines are engineered to have specific genes knocked out, allowing researchers to observe the phenotypic consequences of gene absence. By employing CRISPR-Cas9 technology or similar genome editing techniques, ZFX gene knockout cell lines achieve precise alterations in the genome, which are crucial for elucidating the roles of target genes in various biological pathways and disease processes.

The primary function of ZFX gene knockout cell lines is to enable functional genomics studies whereby the effects of specific gene deletions can be meticulously examined. This is particularly valuable in cancer research, developmental biology, and drug development, as it provides insight into gene interactions, compensatory mechanisms, and potential therapeutic targets. Researchers can utilize these cell lines to assess cellular responses to treatments, investigate gene expression profiles, and elucidate pathways involved in pathologies.

The scientific importance of these cell lines cannot be overstated. Their applications span diverse fields, from basic research to applied sciences, making them invaluable in academic settings, pharmaceutical development, and biotechnology. By allowing for the dissection of complex genetic interactions, these tools contribute significantly to advancements in personalized medicine and targeted therapies.

What sets ZFX gene knockout cell lines apart from alternatives is their high specificity and minimal off-target effects, which ensure reliable and reproducible results. Furthermore, these cell lines are rigorously validated, providing confidence in the data generated from experimentation. Their ease of use also allows researchers to implement them into existing workflows without significant modifications.

For researchers, clinicians, and industry professionals, the ZFX gene knockout cell lines offer a robust solution for dissecting gene function and understanding disease mechanisms. The value they provide lies in enhancing experimental precision and leading to novel insights that could pave the way for innovative therapeutic strategies. With a commitment to quality and innovation, our company is at the forefront of developing advanced biological products, ensuring that our users have access to the latest tools necessary for groundbreaking scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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