Gene: ZFR
Official Full Name: zinc finger RNA binding proteinprovided by HGNC
Gene Summary: This gene encodes an RNA-binding protein characterized by its DZF (domain associated with zinc fingers) domain. The encoded protein may play a role in the nucleocytoplasmic shuttling of another RNA-binding protein, Staufen homolog 2, in neurons. Expression of this gene is regulated through alternative polyadenylation that mediates differential microRNA targeting. Elevated expression of this gene has been observed in human patients with pancreatic cancer and knockdown of this gene may result in reduced viability and invasion of pancreatic cancer cells. [provided by RefSeq, Sep 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO22299 | ZFR Knockout cell line (HeLa) | Human | ZFR | 1:3~1:6 | Negative | Online Inquiry |
KO22300 | ZFR Knockout cell line (HCT 116) | Human | ZFR | 1:2~1:4 | Negative | Online Inquiry |
KO22301 | ZFR Knockout cell line (HEK293) | Human | ZFR | 1:3~1:6 | Negative | Online Inquiry |
ZFR Gene Knockout Cell Lines are highly specialized biological products designed to facilitate advanced genetic research by enabling the precise inactivation of the ZFR gene in various cellular contexts. These engineered cell lines employ a state-of-the-art CRISPR-Cas9 gene editing technology, ensuring that the target gene is efficiently disrupted, which allows researchers to study the functions and pathways associated with ZFR and its implications in various biological processes.
The primary function of ZFR Gene Knockout Cell Lines is to serve as a model system for examining the roles of the ZFR gene in cellular processes such as proliferation, differentiation, and response to external stimuli. By achieving targeted gene knockouts, researchers can elucidate the contributions of ZFR to disease models, particularly in cancer and developmental biology. The mechanism hinges on the creation of double-strand breaks in the genomic DNA, subsequently leading to non-homologous end joining repair processes that disrupt gene function effectively.
The scientific importance of these cell lines extends to their application in both fundamental and translational research settings. They provide a critical platform for drug discovery and toxicology studies, enabling scientists to explore the therapeutic potential of targeting ZFR in various disease states. The ability to manipulate gene expression with precision enhances the capacity for investigating genetic interactions and cellular signaling pathways.
Compared to alternative models, ZFR Gene Knockout Cell Lines offer unparalleled specificity, reproducibility, and ease of use. Conventional knockout methods often suffer from off-target effects and variable outcomes, whereas our precise CRISPR-based approach ensures consistent genetic modification. Furthermore, these cell lines are commercially available, reducing the time and resources typically required for the generation of custom knockout models.
For researchers and clinicians seeking to further our understanding of ZFR's role in biology, these knockout cell lines represent a valuable resource. Their availability accelerates experimental timelines, streamlining the process of generating insights that could lead to novel therapeutic strategies and enhanced patient care.
Our company prides itself on leveraging cutting-edge technologies and extensive expertise in genetic engineering to deliver high-quality biological products, including ZFR Gene Knockout Cell Lines, that empower scientists and clinicians in their pursuit of discovery and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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