Gene: ZC3HC1
Official Full Name: zinc finger C3HC-type containing 1provided by HGNC
Gene Summary: This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO22441 | ZC3HC1 Knockout cell line (HeLa) | Human | ZC3HC1 | 1:3~1:6 | Negative | Online Inquiry |
KO22442 | ZC3HC1 Knockout cell line (HCT 116) | Human | ZC3HC1 | 1:2~1:4 | Negative | Online Inquiry |
KO22443 | ZC3HC1 Knockout cell line (HEK293) | Human | ZC3HC1 | 1:3~1:6 | Negative | Online Inquiry |
KO22444 | ZC3HC1 Knockout cell line (A549) | Human | ZC3HC1 | 1:3~1:4 | Negative | Online Inquiry |
ZC3HC1 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to study the functional role of the ZC3HC1 gene, which encodes a zinc finger protein involved in various cellular processes, including regulation of gene expression and response to stress. The targeted knockout of this gene enables researchers to observe the resulting phenotypic changes, thereby elucidating its involvement in critical biological pathways.
These knockout cell lines operate through a precise CRISPR/Cas9-mediated editing technique that introduces targeted double-strand breaks in the ZC3HC1 locus, leading to cellular repair mechanisms that disrupt gene function. This methodology not only enhances gene targeting efficiency but also allows for a high degree of specificity, minimizing off-target effects. By providing a powerful tool for gene manipulation, these cell lines facilitate the investigation of gene function in a controlled setting.
The scientific importance of ZC3HC1 Gene Knockout Cell Lines extends to both basic and applied research. They are invaluable for investigating disease models, especially in cancer and immune responses, where the ZC3HC1 gene may play a pivotal role. Furthermore, they serve as a platform for drug discovery applications, allowing scientists to identify potential therapeutic targets and evaluate drug efficacy.
What sets our ZC3HC1 Gene Knockout Cell Lines apart from competitors is the quality assurance in the generation of the knockout, characterized by a robust validation process that confirms the successful disruption of the gene. Additionally, our cell lines are readily accessible and user-friendly, enabling researchers to incorporate them seamlessly into their experimental workflows.
Ultimately, these cell lines represent a significant advancement in the study of gene function, providing researchers with a unique opportunity to explore complex biological mechanisms. Our company prides itself on its deep expertise in genetic engineering and cell line development, ensuring that we deliver high-quality, reliable tools that empower the scientific community in achieving groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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